P73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis

F. Talos, A. Abraham, A. V. Vaseva, L. Holembowski, S. E. Tsirka, A. Scheel, D. Bode, M. Dobbelstein, W. Brück, U. M. Moll

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

The p53 family member p73 is essential for brain development, but its precise role and scope remain unclear. Global p73 deficiency determines an overt and highly penetrant brain phenotype marked by cortical hypoplasia with ensuing hydrocephalus and hippocampal dysgenesis. The ΔNp73 isoform is known to function as a prosurvival factor of mature postmitotic neurons. In this study, we define a novel essential role of p73 in the regulation of the neural stem cell compartment. In both embryonic and adult neurogenesis, p73 has a critical role in maintaining an adequate neurogenic pool by promoting self-renewal and proliferation and inhibiting premature senescence of neural stem and early progenitor cells. Thus, products of the p73 gene locus are essential maintenance factors in the central nervous system, whose broad action stretches across the entire differentiation arch from stem cells to mature postmitotic neurons.

Original languageEnglish (US)
Pages (from-to)1816-1829
Number of pages14
JournalCell Death and Differentiation
Volume17
Issue number12
DOIs
StatePublished - Dec 2010
Externally publishedYes

Keywords

  • adult neurogenesis
  • embryonic neurogenesis
  • neural stem cells
  • p73
  • p73 isoforms

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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