TY - JOUR
T1 - Oximetric quantitation of intracardiac left-to-right shunting
T2 - Limitations of the Qp Qs ratio
AU - Cigarroa, Ricardo G.
AU - Lange, Richard A.
AU - Hillis, L. David
N1 - Funding Information:
From the Departments of Medicine (Cardiology and Vascular Medi-tine), Radiology, Vascular Surgery and Biomedical Research, St. Elizabeth’s Hospital, 736 Cambridge Street, Boston, Massachusetts0 2135, and Tufts University School of Medicine, Boston. This study was sup ported in part by grants HL 32747 and HL 40518 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; the Eleanor Naylor Dana Charitable Trust, New York, New York; and the John and Cora Davis Foundation, Washington, DC. Manuscript received February 23, 1989; revised manuscript receiveda nd acceptedM ay 1, 1989.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1989/7/15
Y1 - 1989/7/15
N2 - For over 40 years, analysis of the blood oxygen content in the right heart chambers has been used to detect and quantitate intracardiac left-to-right shunting.1 Using the Fick principle, pulmonary and systemic blood flows are calculated and then their ratio ( Qp Qs) is determined. Subsequently, numerous studies-including indicator dilution,2 radionuclide angiocardiography3,4 and Doppler echocardiography5,6-have used this ratio as the gold standard for measuring intracardiac left-to-right shunting, but its widespread use as such suggests an insufficient understanding of its potential inaccuracies. We performed this study to assess and quantitate the limitations of the Qp Qs ratio in patients with intracardiac left-to-right shunting.
AB - For over 40 years, analysis of the blood oxygen content in the right heart chambers has been used to detect and quantitate intracardiac left-to-right shunting.1 Using the Fick principle, pulmonary and systemic blood flows are calculated and then their ratio ( Qp Qs) is determined. Subsequently, numerous studies-including indicator dilution,2 radionuclide angiocardiography3,4 and Doppler echocardiography5,6-have used this ratio as the gold standard for measuring intracardiac left-to-right shunting, but its widespread use as such suggests an insufficient understanding of its potential inaccuracies. We performed this study to assess and quantitate the limitations of the Qp Qs ratio in patients with intracardiac left-to-right shunting.
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U2 - 10.1016/0002-9149(89)90471-2
DO - 10.1016/0002-9149(89)90471-2
M3 - Article
C2 - 2741836
AN - SCOPUS:0024400104
VL - 64
SP - 246
EP - 247
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 3
ER -