Oxidative stress interactions with polyglycolide particles

John P. Schmitz; Gustavo Zardeneta; C. Mauli Agrawal; Tim Lee; Kyriacos Athanasiou; Fabian W. Cordewener; Stephen B. Milam

Oxidative stress interactions with polyglycolide particles

John P. Schmitz, Gustavo Zardeneta, C. Mauli Agrawal, Tim Lee, Kyriacos Athanasiou, Fabian W. Cordewener, Stephen B. Milam

Orthopaedics

Research output: Contribution to conference › Paper › peer-review

Abstract

The free radical production of cells exposed to polyglycolide (PLG) particles was measured to examine the oxidative burst occurring in cells after exposure to biodegradable poly(α-hydroxyl) acid surgical implants. It demonstrated that free radicals were only produced in response to protein-coated particles. The particle-bound proteins were present in a denatured form and it was in this conformation that elicits the foreign-body response. The oxidative burst in cells exposed to PLG particles occurs only when non-native proteins were bound to PLG.

Original language	English (US)
Number of pages	1
State	Published - 1998
Event	Proceedings of the 1998 17th Southern Biomedical Engineering Conference - San Antonio, TX, USA Duration: Feb 6 1998 → Feb 8 1998

Other

Other	Proceedings of the 1998 17th Southern Biomedical Engineering Conference
City	San Antonio, TX, USA
Period	2/6/98 → 2/8/98

ASJC Scopus subject areas

Engineering(all)

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Oxidative stress interactions with polyglycolide particles. / Schmitz, John P.; Zardeneta, Gustavo; Agrawal, C. Mauli; Lee, Tim; Athanasiou, Kyriacos; Cordewener, Fabian W.; Milam, Stephen B.

1998. Paper presented at Proceedings of the 1998 17th Southern Biomedical Engineering Conference, San Antonio, TX, USA, .

Research output: Contribution to conference › Paper › peer-review

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AU - Schmitz, John P.

AU - Zardeneta, Gustavo

AU - Agrawal, C. Mauli

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AU - Athanasiou, Kyriacos

AU - Cordewener, Fabian W.

AU - Milam, Stephen B.

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AB - The free radical production of cells exposed to polyglycolide (PLG) particles was measured to examine the oxidative burst occurring in cells after exposure to biodegradable poly(α-hydroxyl) acid surgical implants. It demonstrated that free radicals were only produced in response to protein-coated particles. The particle-bound proteins were present in a denatured form and it was in this conformation that elicits the foreign-body response. The oxidative burst in cells exposed to PLG particles occurs only when non-native proteins were bound to PLG.

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