Oxidative stress interactions with polyglycolide particles

John P. Schmitz, Gustavo Zardeneta, C. Mauli Agrawal, Tim Lee, Kyriacos Athanasiou, Fabian W. Cordewener, Stephen B. Milam

Research output: Contribution to conferencePaperpeer-review

Abstract

The free radical production of cells exposed to polyglycolide (PLG) particles was measured to examine the oxidative burst occurring in cells after exposure to biodegradable poly(α-hydroxyl) acid surgical implants. It demonstrated that free radicals were only produced in response to protein-coated particles. The particle-bound proteins were present in a denatured form and it was in this conformation that elicits the foreign-body response. The oxidative burst in cells exposed to PLG particles occurs only when non-native proteins were bound to PLG.

Original languageEnglish (US)
Number of pages1
StatePublished - 1998
EventProceedings of the 1998 17th Southern Biomedical Engineering Conference - San Antonio, TX, USA
Duration: Feb 6 1998Feb 8 1998

Other

OtherProceedings of the 1998 17th Southern Biomedical Engineering Conference
CitySan Antonio, TX, USA
Period2/6/982/8/98

ASJC Scopus subject areas

  • Engineering(all)

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