Oxidative stress induced by aluminum oxide nanomaterials after acute oral treatment in Wistar rats

P. V. Prabhakar, Utkarsh A. Reddy, S. P. Singh, A. Balasubramanyam, M. F. Rahman, S. Indu Kumari, Sachin B. Agawane, U. S.N. Murty, Paramjit Grover, Mohammed Mahboob

Research output: Contribution to journalArticlepeer-review

117 Scopus citations

Abstract

This study investigated the oxidative stress induced after acute oral treatment with 500, 1000 and 2000mg kg-1 doses of Al2O3-30 and -40nm and bulk Al2O3 in Wistar rats. Both the nanomaterials induced significant oxidative stress in a dose-dependent manner in comparison to the bulk. There was no significant difference between the two nanomaterials. However, the effect decreased with increase with time after treatment. The histopathological examination showed lesions only in liver with Al2O3 nanomaterials at 2000mg kg-1.

Original languageEnglish (US)
Pages (from-to)436-445
Number of pages10
JournalJournal of Applied Toxicology
Volume32
Issue number6
DOIs
StatePublished - Jun 2012
Externally publishedYes

Keywords

  • Acute oral toxicity
  • Aluminium oxide nanomaterials
  • Antioxidant enzymes
  • Histopathology
  • Oxidative stress
  • Wistar rat

ASJC Scopus subject areas

  • Toxicology

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