Oxidative stress induced by aluminum oxide nanomaterials after acute oral treatment in Wistar rats

P. V. Prabhakar; Utkarsh A. Reddy; S. P. Singh; A. Balasubramanyam; M. F. Rahman; S. Indu Kumari; Sachin B. Agawane; U. S.N. Murty; Paramjit Grover; Mohammed Mahboob

doi:10.1002/jat.1775

Oxidative stress induced by aluminum oxide nanomaterials after acute oral treatment in Wistar rats

P. V. Prabhakar, Utkarsh A. Reddy, S. P. Singh, A. Balasubramanyam, M. F. Rahman, S. Indu Kumari, Sachin B. Agawane, U. S.N. Murty, Paramjit Grover, Mohammed Mahboob

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

This study investigated the oxidative stress induced after acute oral treatment with 500, 1000 and 2000mg kg^-1 doses of Al₂O₃-30 and -40nm and bulk Al₂O₃ in Wistar rats. Both the nanomaterials induced significant oxidative stress in a dose-dependent manner in comparison to the bulk. There was no significant difference between the two nanomaterials. However, the effect decreased with increase with time after treatment. The histopathological examination showed lesions only in liver with Al₂O₃ nanomaterials at 2000mg kg^-1.

Original language	English (US)
Pages (from-to)	436-445
Number of pages	10
Journal	Journal of Applied Toxicology
Volume	32
Issue number	6
DOIs	https://doi.org/10.1002/jat.1775
State	Published - Jun 2012
Externally published	Yes

Keywords

Acute oral toxicity
Aluminium oxide nanomaterials
Antioxidant enzymes
Histopathology
Oxidative stress
Wistar rat

ASJC Scopus subject areas

Toxicology

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10.1002/jat.1775

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title = "Oxidative stress induced by aluminum oxide nanomaterials after acute oral treatment in Wistar rats",

abstract = "This study investigated the oxidative stress induced after acute oral treatment with 500, 1000 and 2000mg kg-1 doses of Al2O3-30 and -40nm and bulk Al2O3 in Wistar rats. Both the nanomaterials induced significant oxidative stress in a dose-dependent manner in comparison to the bulk. There was no significant difference between the two nanomaterials. However, the effect decreased with increase with time after treatment. The histopathological examination showed lesions only in liver with Al2O3 nanomaterials at 2000mg kg-1.",

keywords = "Acute oral toxicity, Aluminium oxide nanomaterials, Antioxidant enzymes, Histopathology, Oxidative stress, Wistar rat",

author = "Prabhakar, {P. V.} and Reddy, {Utkarsh A.} and Singh, {S. P.} and A. Balasubramanyam and Rahman, {M. F.} and {Indu Kumari}, S. and Agawane, {Sachin B.} and Murty, {U. S.N.} and Paramjit Grover and Mohammed Mahboob",

year = "2012",

month = jun,

doi = "10.1002/jat.1775",

language = "English (US)",

volume = "32",

pages = "436--445",

journal = "Journal of Applied Toxicology",

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publisher = "John Wiley and Sons Ltd",

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TY - JOUR

T1 - Oxidative stress induced by aluminum oxide nanomaterials after acute oral treatment in Wistar rats

AU - Prabhakar, P. V.

AU - Reddy, Utkarsh A.

AU - Singh, S. P.

AU - Balasubramanyam, A.

AU - Rahman, M. F.

AU - Indu Kumari, S.

AU - Agawane, Sachin B.

AU - Murty, U. S.N.

AU - Grover, Paramjit

AU - Mahboob, Mohammed

PY - 2012/6

Y1 - 2012/6

N2 - This study investigated the oxidative stress induced after acute oral treatment with 500, 1000 and 2000mg kg-1 doses of Al2O3-30 and -40nm and bulk Al2O3 in Wistar rats. Both the nanomaterials induced significant oxidative stress in a dose-dependent manner in comparison to the bulk. There was no significant difference between the two nanomaterials. However, the effect decreased with increase with time after treatment. The histopathological examination showed lesions only in liver with Al2O3 nanomaterials at 2000mg kg-1.

AB - This study investigated the oxidative stress induced after acute oral treatment with 500, 1000 and 2000mg kg-1 doses of Al2O3-30 and -40nm and bulk Al2O3 in Wistar rats. Both the nanomaterials induced significant oxidative stress in a dose-dependent manner in comparison to the bulk. There was no significant difference between the two nanomaterials. However, the effect decreased with increase with time after treatment. The histopathological examination showed lesions only in liver with Al2O3 nanomaterials at 2000mg kg-1.

KW - Acute oral toxicity

KW - Aluminium oxide nanomaterials

KW - Antioxidant enzymes

KW - Histopathology

KW - Oxidative stress

KW - Wistar rat

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Oxidative stress induced by aluminum oxide nanomaterials after acute oral treatment in Wistar rats

Abstract

Keywords

ASJC Scopus subject areas

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