Oxidative stress in newborns

Eloisa Gitto, Gabriella D'Angelo, Salvatore Aversa, Russel J. Reiter

Research output: Chapter in Book/Report/Conference proceedingChapter


Newborns, and especially those delivered preterm, are probably more prone to oxidative stress than individuals later in life. Even during pregnancy, the greater demand for oxygen increases the rate of production of reactive oxygen species (ROS), and moreover, women with normal pregnancies have a state of high oxidative stress compared to nonpregnant women. In addition, there appears to be increased ROS production in the placenta of preeclamptic women. In comparison with healthy adults, newborn infants have lower levels of plasma antioxidants such as vitamin E, b-carotene, and sulphydryl groups, lower levels of plasma metal binding proteins including ceruloplasmin and transferrin, and reduced activity of erythrocyte superoxide dismutase.

Original languageEnglish (US)
Title of host publicationSystems Biology of Free Radicals and Antioxidants
PublisherSpringer-Verlag Berlin Heidelberg
Number of pages20
ISBN (Electronic)9783642300189
ISBN (Print)3642300170, 9783642300172
StatePublished - May 1 2012
Externally publishedYes


  • Antioxidants
  • Free radicals
  • Melatonin
  • Neonatal diseases
  • Newborns
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine(all)


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