Oxidative stress, cytokine/chemokine and disruption of blood-brain barrier in neonate rats after meningitis by streptococcus agalactiae

Tatiana Barichello, Joelson C. Lemos, Jaqueline S. Generoso, Andreza L. Cipriano, Graziele L. Milioli, Danielle M. Marcelino, Francieli Vuolo, Fabricia Petronilho, Felipe Dal-Pizzol, Márcia Carvalho Vilela, Antonio Lucio Teixeira

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

We verify the levels of cytokine/chemokine, myeloperoxidase activity, oxidative stress and disruption of BBB in hippocampus and cortex of the neonate Wistar rats after meningitis by S. agalactiae. In the hippocampus the levels were increased of CINC-1 at 6 h and 12 h, IL-1b at 6, 12 and 24 h, IL-6 at 6, 24 and 96 h, IL-10 at 24, 48 and 96 h and TNF-a at 24 h and 96 h. In the cortex the CINC-1 and IL-1b levels were found increased at 6 h. The MPO activity was significantly elevated at 24, 48 and 98 h inhippocampus and at 6, 12, 24, 48 and 96 h in the cortex. The breakdown of BBB started at 12 h.TBARS levels were elevated in the hippocampus at 6, 12, 24, 48, 72 and 96 h and cortex at 72 and 96 h. Protein carbonyls were elevated in the hippocampus and cortex at 6, 24, 48, 72 and 96 h. There was a decrease of SOD activity in hippocampus and in cortex. Catalase activity was elevated in hippocampus at 6 h and in the cortex at 12 and 96 h. Neonatal bacterial infections of the CNS are severe, the interference with the complex network of cytokines/chemokine, other inflammatory mediators and oxidants tend to aggravate the illness and can be involved in the breakdown of the BBB.

Original languageEnglish (US)
Pages (from-to)1922-1930
Number of pages9
JournalNeurochemical Research
Volume36
Issue number10
DOIs
StatePublished - Oct 2011
Externally publishedYes

Keywords

  • Cytokine/chemokine
  • Meningitis
  • Myeloperoxidase activity
  • Oxidative stress
  • Streptococcus agalactiae

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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