Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 145-150 |
| Number of pages | 6 |
| Journal | Neuroendocrinology Letters |
| Volume | 20 |
| Issue number | 3-4 |
| State | Published - 1999 |
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ASJC Scopus subject areas
- Endocrinology
- Neuroscience(all)
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Oxidative damage to nuclear DNA : Amelioration by melatonin. / Reiter, Russel J.
In: Neuroendocrinology Letters, Vol. 20, No. 3-4, 1999, p. 145-150.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oxidative damage to nuclear DNA
T2 - Amelioration by melatonin
AU - Reiter, Russel J
PY - 1999
Y1 - 1999
N2 - The indoleamine melatonin, a product of tryptophan metabolism in the pineal gland, is a free radical scavenger and antioxidant. This brief review summarizes melatonin's ability to protect nuclear DNA from oxidative damage. Using a variety of different cytogenetic, biochemical and molecular biological methods, a number of investigators have demonstrated melatonin's ability to protect DNA from the physical agent ionizing radiation, the herbicide paraquat, the carcinogen safrole, the excitotoxin kainic acid, the heavy metal chromium (VI), and a wide number of mutagens. Since these agents damage DNA because they generate free radicals, the observations are consistent with melatonin being a radical scavenger and antioxidant.
AB - The indoleamine melatonin, a product of tryptophan metabolism in the pineal gland, is a free radical scavenger and antioxidant. This brief review summarizes melatonin's ability to protect nuclear DNA from oxidative damage. Using a variety of different cytogenetic, biochemical and molecular biological methods, a number of investigators have demonstrated melatonin's ability to protect DNA from the physical agent ionizing radiation, the herbicide paraquat, the carcinogen safrole, the excitotoxin kainic acid, the heavy metal chromium (VI), and a wide number of mutagens. Since these agents damage DNA because they generate free radicals, the observations are consistent with melatonin being a radical scavenger and antioxidant.
KW - Antioxidant
KW - Melatonin
KW - Pineal gland
UR - http://www.scopus.com/inward/record.url?scp=0032738514&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032738514&partnerID=8YFLogxK
M3 - Article
VL - 20
SP - 145
EP - 150
JO - Neuroendocrinology Letters
JF - Neuroendocrinology Letters
SN - 0172-780X
IS - 3-4
ER -