Oxidative damage to nuclear DNA

Amelioration by melatonin

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalNeuroendocrinology Letters
Volume20
Issue number3-4
StatePublished - 1999

Fingerprint

Melatonin
DNA
DNA Damage
Safrole
Antioxidants
Free Radical Scavengers
Paraquat
Pineal Gland
Kainic Acid
Neurotoxins
Mutagens
Herbicides
Heavy Metals
Ionizing Radiation
Cytogenetics
Tryptophan
Carcinogens
Free Radicals
Research Personnel

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Oxidative damage to nuclear DNA : Amelioration by melatonin. / Reiter, Russel J.

In: Neuroendocrinology Letters, Vol. 20, No. 3-4, 1999, p. 145-150.

Research output: Contribution to journalArticle

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abstract = "The indoleamine melatonin, a product of tryptophan metabolism in the pineal gland, is a free radical scavenger and antioxidant. This brief review summarizes melatonin's ability to protect nuclear DNA from oxidative damage. Using a variety of different cytogenetic, biochemical and molecular biological methods, a number of investigators have demonstrated melatonin's ability to protect DNA from the physical agent ionizing radiation, the herbicide paraquat, the carcinogen safrole, the excitotoxin kainic acid, the heavy metal chromium (VI), and a wide number of mutagens. Since these agents damage DNA because they generate free radicals, the observations are consistent with melatonin being a radical scavenger and antioxidant.",
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