Oxidative damage to myelin proteins accompanies peripheral nerve motor dysfunction in aging C57BL/6 male mice

Ryan Hamilton, Michael Walsh, Rashmi Singh, Karl A Rodriguez, Xiaoli Gao, Md Mizanur Rahman, Asish Chaudhuri, Arunabh Bhattacharya

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Aging is associated with a decline in peripheral nerve function of both motor and sensory nerves. The decline in function of peripheral sensorimotor nerves with aging has been linked to sarcopenia, the age-related decline in muscle mass and function that significantly compromises the quality of life in older humans. In this study, we report a significant increase in oxidized fatty acids and insoluble protein carbonyls in sciatic nerves of aged C57BL/6 male mice (28–30 mo) that exhibit a profound decline in motor nerve function and degenerative changes in both axon and myelin structure, compared to young mice (6–8 mo). Our data further suggests that this age-related loss of function of peripheral motor nerves is likely precipitated by changes in mechanisms that protect and/or repair oxidative damage. We predict that interventions that target these mechanisms may protect against age-related decline in peripheral sensorimotor nerve function and likely improve the debilitating outcome of sarcopenia in older humans.

Original languageEnglish (US)
Pages (from-to)47-52
Number of pages6
JournalJournal of the Neurological Sciences
Volume370
DOIs
StatePublished - Nov 15 2016

Keywords

  • Aging
  • Carbonylation
  • Lipoxygenase
  • Oxidative stress
  • Peripheral nerves

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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