Oxidative damage to mitochondria and aging

Holly Van Remmen, Arlan Richardson

Research output: Contribution to journalArticle

193 Scopus citations

Abstract

Oxidative damage has been implicated to be a major factor in the decline in physiologic function that occurs during the aging process. Because mitochondria are a primary site of generation of reactive oxygen species, they have become a major focus of research in this area. Increased oxidative damage to mitochondrial proteins, lipid and DNA has been reported to occur with age in several tissues in a variety of organisms. Decreased activity of electron transport chain complexes and increased release of reactive oxygen species from the mitochondria with age suggest that alterations in mitochondrial function occur with age as a consequence of increased oxidative damage. In addition, age-related alterations in the mitochondrial pathway of apoptosis, which could have profound affects on the physiological function of a tissue, could arise from oxidative damage to mitochondria. Alterations in mitochondrial turnover with age could also contribute to an increase in the number of dysfunctional mitochondria with age.

Original languageEnglish (US)
Pages (from-to)957-968
Number of pages12
JournalExperimental Gerontology
Volume36
Issue number7
DOIs
StatePublished - Jan 1 2001

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Keywords

  • Aging
  • Mitochondria
  • Oxidative damage

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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