Oxidative damage to DNA and aging

Holly Van Remmen; Michelle L. Hamilton; A. Richardson

doi:10.1097/00003677-200307000-00009

Oxidative damage to DNA and aging

Holly Van Remmen, Michelle L. Hamilton, A. Richardson

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

Oxidative damage to DNA increases with age in several tissues and animal models, and mitochondrial DNA has a higher level of oxidative damage than nuclear DNA. Dietary restriction extends lifespan and is associated with reduced levels of damage to mitochondrial and nuclear DNA. The effect of exercise on DNA damage appears to be related to the intensity of the exercise.

Original language	English (US)
Pages (from-to)	149-153
Number of pages	5
Journal	Exercise and Sport Sciences Reviews
Volume	31
Issue number	3
DOIs	https://doi.org/10.1097/00003677-200307000-00009
State	Published - Jul 2003

Keywords

Dietary restriction
Exercise
Mitochondrial DNA
Nuclear DNA
Oxidative stress

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

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10.1097/00003677-200307000-00009

Cite this

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title = "Oxidative damage to DNA and aging",

abstract = "Oxidative damage to DNA increases with age in several tissues and animal models, and mitochondrial DNA has a higher level of oxidative damage than nuclear DNA. Dietary restriction extends lifespan and is associated with reduced levels of damage to mitochondrial and nuclear DNA. The effect of exercise on DNA damage appears to be related to the intensity of the exercise.",

keywords = "Dietary restriction, Exercise, Mitochondrial DNA, Nuclear DNA, Oxidative stress",

author = "{Van Remmen}, Holly and Hamilton, {Michelle L.} and A. Richardson",

year = "2003",

month = jul,

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T1 - Oxidative damage to DNA and aging

AU - Van Remmen, Holly

AU - Hamilton, Michelle L.

AU - Richardson, A.

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N2 - Oxidative damage to DNA increases with age in several tissues and animal models, and mitochondrial DNA has a higher level of oxidative damage than nuclear DNA. Dietary restriction extends lifespan and is associated with reduced levels of damage to mitochondrial and nuclear DNA. The effect of exercise on DNA damage appears to be related to the intensity of the exercise.

AB - Oxidative damage to DNA increases with age in several tissues and animal models, and mitochondrial DNA has a higher level of oxidative damage than nuclear DNA. Dietary restriction extends lifespan and is associated with reduced levels of damage to mitochondrial and nuclear DNA. The effect of exercise on DNA damage appears to be related to the intensity of the exercise.

KW - Dietary restriction

KW - Exercise

KW - Mitochondrial DNA

KW - Nuclear DNA

KW - Oxidative stress

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U2 - 10.1097/00003677-200307000-00009

DO - 10.1097/00003677-200307000-00009

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AN - SCOPUS:0038637451

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JO - Exercise and Sport Sciences Reviews

JF - Exercise and Sport Sciences Reviews

SN - 0091-6331

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ER -

Oxidative damage to DNA and aging

Abstract

Keywords

ASJC Scopus subject areas

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