Oxidative damage to DNA and aging

Holly Van Remmen, Michelle L. Hamilton, A. Richardson

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations

Abstract

Oxidative damage to DNA increases with age in several tissues and animal models, and mitochondrial DNA has a higher level of oxidative damage than nuclear DNA. Dietary restriction extends lifespan and is associated with reduced levels of damage to mitochondrial and nuclear DNA. The effect of exercise on DNA damage appears to be related to the intensity of the exercise.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalExercise and Sport Sciences Reviews
Volume31
Issue number3
DOIs
StatePublished - Jul 2003

Keywords

  • Dietary restriction
  • Exercise
  • Mitochondrial DNA
  • Nuclear DNA
  • Oxidative stress

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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