Oxidative damage in the central nervous system

Protection by melatonin

Research output: Contribution to journalArticle

790 Citations (Scopus)

Abstract

Melatonin was recently reported to be an effective free radical scavenger and antioxidant. Melatonin is believed to scavenge the highly toxic hydroxyl radical, the peroxynitrite anion, and possibly the peroxyl radical. Also, secondarily, it reportedly scavenges the superoxide anion radical and it quenches singlet oxygen. Additionally, it stimulates mRNA levels for superoxide dismutase and the activities of glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase (all of which are antioxidative enzymes), thereby increasing its antioxidative capacity. Also, melatonin, at least at some sites, inhibits nitric oxide synthase, a pro- oxidative enzyme. In both in vivo and in vitro experiments melatonin has been shown to reduce lipid peroxidation and oxidative damage to nuclear DNA. While these effects have been observed primarily using pharmacological doses of melatonin, in a small number of experiments melatonin has been found to be physiologically relevant as an antioxidant as well. The efficacy of melatonin in inhibiting oxidative damage has been tested in a variety of neurological disease models where free radicals have been implicated as being in part causative of the condition. Thus, melatonin has been shown prophylactically to reduce amyloid β protein toxicity of Alzheimer's disease, to reduce oxidative damage in several models of Parkinson's disease (dopamine auto- oxidation, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6- hydroxydopamine), to protect against glutamate excitotoxicity, to reduce ischemia-reperfusion injury, to lower neural damage to δ-aminolevulinic acid (phorphyria), hyperbaric hyperoxia and a variety of neural toxins. Since endogenous melatonin levels fall markedly in advanced age, the implication of these findings is that the loss of this antioxidant may contribute to the incidence or severity of some age-associated neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)359-384
Number of pages26
JournalProgress in Neurobiology
Volume56
Issue number3
DOIs
StatePublished - Oct 1998

Fingerprint

Melatonin
Central Nervous System
Antioxidants
Superoxides
Neurological Models
Amyloidogenic Proteins
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Aminolevulinic Acid
Singlet Oxygen
Free Radical Scavengers
Hyperoxia
Peroxynitrous Acid
Glutathione Reductase
Glucosephosphate Dehydrogenase
Poisons
Oxidopamine
Enzymes
Glutathione Peroxidase
Reperfusion Injury
Nitric Oxide Synthase

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Oxidative damage in the central nervous system : Protection by melatonin. / Reiter, Russel J.

In: Progress in Neurobiology, Vol. 56, No. 3, 10.1998, p. 359-384.

Research output: Contribution to journalArticle

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