Oxidation of amines by flavoproteins

Paul F. Fitzpatrick

Research output: Contribution to journalReview article

141 Scopus citations

Abstract

Many flavoproteins catalyze the oxidation of primary and secondary amines, with the transfer of a hydride equivalent from a carbon-nitrogen bond to the flavin cofactor. Most of these amine oxidases can be classified into two structural families, the D-amino acid oxidase/sarcosine oxidase family and the monoamine oxidase family. This review discusses the present understanding of the mechanisms of amine and amino acid oxidation by flavoproteins, focusing on these two structural families.

Original languageEnglish (US)
Pages (from-to)13-25
Number of pages13
JournalArchives of Biochemistry and Biophysics
Volume493
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • D-amino acid oxidase
  • Enzyme mechanisms
  • Flavoproteins
  • Monoamine oxidase

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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