Overview of the cardio-metabolic impact of the COVID-19 pandemic

Maryam Barkhordarian, Arezoo Behbood, Maryam Ranjbar, Zahra Rahimian, Anand Prasad

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Evidence has shown that cardiometabolic disorders (CMDs) are amongst the top contributors to COVID-19 infection morbidity and mortality. The reciprocal impact of COVID-19 infection and the most common CMDs, the risk factors for poor composite outcome among patients with one or several underlying diseases, the effect of common medical management on CMDs and their safety in the context of acute COVID-19 infection are reviewed. Later on, the changes brought by the COVID-19 pandemic quarantine on the general population’s lifestyle (diet, exercise patterns) and metabolic health, acute cardiac complications of different COVID-19 vaccines and the effect of CMDs on the vaccine efficacy are discussed. Our review identified that the incidence of COVID-19 infection is higher among patients with underlying CMDs such as hypertension, diabetes, obesity and cardiovascular disease. Also, CMDs increase the risk of COVID-19 infection progression to severe disease phenotypes (e.g. hospital and/or ICU admission, use of mechanical ventilation). Lifestyle modification during COVID-19 era had a great impact on inducing and worsening of CMDs. Finally, the lower efficacy of COVID-19 vaccines was found in patients with metabolic disease.

Original languageEnglish (US)
Pages (from-to)477-490
Number of pages14
Issue number3
StatePublished - Jun 2023
Externally publishedYes


  • COVID-19
  • Cardiovascular disease
  • Diabetes
  • Hyperlipidemia
  • Hypertension
  • Obesity

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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