Overview of CNS Vaccines-Pediatrics

Joanna E. Gernsback; John Paul G. Kolcun; Sheikh C. Ali; Ricardo J. Komotar

doi:10.1016/B978-0-12-812100-9.00056-5

Overview of CNS Vaccines-Pediatrics

Joanna E. Gernsback, John Paul G. Kolcun, Sheikh C. Ali, Ricardo J. Komotar

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Vaccine immunotherapy for pediatric CNS malignancy is a new and developing field, primarily aimed at glial tumors. Vaccines typically must be found safe and effective in adults before being tested in children. There are three major types of tumor vaccines: dendritic cell (DC), peptide, and vector-based. All vaccines directed at pediatric CNS tumors currently remain in pilot or Phase I trials, evaluating feasibility and safety, respectively. Immune response and improved clinical outcomes have been documented as secondary measures in some cases. In this chapter, we will present a thorough review of vaccine therapy for pediatric CNS tumors.

Original language	English (US)
Title of host publication	Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	707-711
Number of pages	5
ISBN (Print)	9780128121009
DOIs	https://doi.org/10.1016/B978-0-12-812100-9.00056-5
State	Published - Apr 24 2018
Externally published	Yes

Keywords

Brain tumor
Glioma
Immunotherapy
Pediatric
Vaccine

ASJC Scopus subject areas

General Medicine
General Neuroscience

Access to Document

10.1016/B978-0-12-812100-9.00056-5

Cite this

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AU - Gernsback, Joanna E.

AU - Kolcun, John Paul G.

AU - Ali, Sheikh C.

AU - Komotar, Ricardo J.

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Y1 - 2018/4/24

N2 - Vaccine immunotherapy for pediatric CNS malignancy is a new and developing field, primarily aimed at glial tumors. Vaccines typically must be found safe and effective in adults before being tested in children. There are three major types of tumor vaccines: dendritic cell (DC), peptide, and vector-based. All vaccines directed at pediatric CNS tumors currently remain in pilot or Phase I trials, evaluating feasibility and safety, respectively. Immune response and improved clinical outcomes have been documented as secondary measures in some cases. In this chapter, we will present a thorough review of vaccine therapy for pediatric CNS tumors.

AB - Vaccine immunotherapy for pediatric CNS malignancy is a new and developing field, primarily aimed at glial tumors. Vaccines typically must be found safe and effective in adults before being tested in children. There are three major types of tumor vaccines: dendritic cell (DC), peptide, and vector-based. All vaccines directed at pediatric CNS tumors currently remain in pilot or Phase I trials, evaluating feasibility and safety, respectively. Immune response and improved clinical outcomes have been documented as secondary measures in some cases. In this chapter, we will present a thorough review of vaccine therapy for pediatric CNS tumors.

KW - Brain tumor

KW - Glioma

KW - Immunotherapy

KW - Pediatric

KW - Vaccine

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BT - Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy

PB - Elsevier Inc.

ER -

Overview of CNS Vaccines-Pediatrics

Abstract

Keywords

ASJC Scopus subject areas

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