Overview for the histone codes for DNA repair

Elizabeth A. Williamson, Justin W. Wray, Pranshu Bansal, Robert Hromas

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Scopus citations

Abstract

DNA damage occurs continuously as a result of various factors - intracellular metabolism, replication, and exposure to genotoxic agents, such as ionizing radiation and chemotherapy. If left unrepaired, this damage could result in changes or mutations within the cell genomic material. There are a number of different pathways that the cell can utilize to repair these DNA breaks. However, it is of utmost interest to know how the DNA damage is signaled to the various DNA pathways. As DNA damage occurs within the chromatin, we postulate that modifications of histones are important for signaling the position of DNA damage, recruiting the DNA repair proteins to the site of damage, and creating an open structure such that the repair proteins can access the site of damage. We discuss the modifications that occur on the histones and the manner in which they relate to the type of damage that has occurred as well as the DNA repair pathways that are activated.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Pages207-227
Number of pages21
DOIs
StatePublished - 2012
Externally publishedYes

Publication series

NameProgress in Molecular Biology and Translational Science
Volume110
ISSN (Print)1877-1173

Keywords

  • Acetylation
  • DNA repair
  • Histone
  • Methylation
  • Phosphorylation
  • Ubiquitylation

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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    Williamson, E. A., Wray, J. W., Bansal, P., & Hromas, R. (2012). Overview for the histone codes for DNA repair. In Progress in Molecular Biology and Translational Science (pp. 207-227). (Progress in Molecular Biology and Translational Science; Vol. 110). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-387665-2.00008-0