Over-expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma

R. Ramirez, D. Hsu, A. Patel, C. Fenton, C. Dinauer, R. M. Tuttle, G. L. Francis

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

OBJECTIVE: The study determined if hepatocyte growth factor/scatter factor (HGF/SF) or the HGF/SF receptor (cMET) might be important for metastasis in thyroid cancer. DESIGN: We examined HGF/SF and cMET expression by immunohistochemistry in a retrospective group of benign and malignant thyroid lesions from children and young adults, and correlated the intensity of expression with clinical outcome. PATIENTS: Patients included 42 children and young adults with papillary thyroid carcinomas (PTC), seven with follicular thyroid carcinomas (FTC), two with medullary thyroid carcinomas (MTC), 14 with benign thyroid disorders, and two with normal thyroids. MEASUREMENTS: Expression of cMET was graded from 0 (absent) to 4 (intense); and HGF/SF expression was graded from 0 (absent-minimal) to 3 (diffuse and intense). RESULTS: cMET staining was greater in PTC (mean intensity 2.3 ± 0.4 vs. 0.8 ± 0.2, P<0.005) and FTC (2.4 ± 0.6 VS. 0.8 ± 0.2, P=0.04) than benign lesions (0.8 ± 0.2) or normal thyroids (0.4 ± 0.5). PTC with intense cMET staining had shorter disease free survival (P=0.05) and increased HGF/SF staining (r=0.39, P=0-017). HGF/SF correlated with the extent of disease at diagnosis (r=0.33, P=0.049). Patients with PTC were stratified into quartiles based on combined cMET and HGF/SF staining. Those with intense cMET and HGF/SF staining were younger (P=0.05), and had reduced disease free survival (P=0.03). CONCLUSIONS: We conclude that increased cMET and HGF/SF expression is associated with a high risk for metastasis and recurrence in children and young adults with papillary thyroid carcinoma.

Original languageEnglish (US)
Pages (from-to)635-644
Number of pages10
JournalClinical Endocrinology
Volume53
Issue number5
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Over-expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma'. Together they form a unique fingerprint.

Cite this