Ovarian and steroidal influences on neuroendocrine aging processes in female rodents

Caleb E. Finch; Charles V. Mobbs; Leda S. Felicio; James F. Nelson

doi:10.1210/edrv-5-4-467

Ovarian and steroidal influences on neuroendocrine aging processes in female rodents

Caleb E. Finch, Charles V. Mobbs, Leda S. Felicio, James F. Nelson

Research output: Contribution to journal › Article › peer-review

267 Scopus citations

Abstract

Some MAMMALIAN aging processes involve effects of steroids on the brain and pituitary. An ovarydependent, neuroendocrine aging syndrome of laboratory rats and mice is described in this article. This syndrome can be attenuated during aging by chronic ovariectomy and can be prematurely induced in young rodents by sustained exposure to estradiol (E₂). The limited follicular stock in the ovary is proposed to be a major pacemaker of aging in this neuroendocrine syndrome; ovarian aging may interact with neuroendocrine aging. Ovary-independent neuroendocrine changes occur as well. We also discuss developmental influences on adult aging in rodents and other examples in which adult lower mammals are sensitive to long lasting effects of steroids on the brain and pituitary. Possible molecular mechanisms are considered. In view of the long lasting effects of E₂ and other steroids on lower mammals, the potential for long term effects of ovarian steroids on the human brain and pituitary warrants continued evaluation.

Original language	English (US)
Pages (from-to)	467-497
Number of pages	31
Journal	Endocrine Reviews
Volume	5
Issue number	4
DOIs	https://doi.org/10.1210/edrv-5-4-467
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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title = "Ovarian and steroidal influences on neuroendocrine aging processes in female rodents",

abstract = "Some MAMMALIAN aging processes involve effects of steroids on the brain and pituitary. An ovarydependent, neuroendocrine aging syndrome of laboratory rats and mice is described in this article. This syndrome can be attenuated during aging by chronic ovariectomy and can be prematurely induced in young rodents by sustained exposure to estradiol (E2). The limited follicular stock in the ovary is proposed to be a major pacemaker of aging in this neuroendocrine syndrome; ovarian aging may interact with neuroendocrine aging. Ovary-independent neuroendocrine changes occur as well. We also discuss developmental influences on adult aging in rodents and other examples in which adult lower mammals are sensitive to long lasting effects of steroids on the brain and pituitary. Possible molecular mechanisms are considered. In view of the long lasting effects of E2 and other steroids on lower mammals, the potential for long term effects of ovarian steroids on the human brain and pituitary warrants continued evaluation.",

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AU - Finch, Caleb E.

AU - Mobbs, Charles V.

AU - Felicio, Leda S.

AU - Nelson, James F.

PY - 1984

Y1 - 1984

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AB - Some MAMMALIAN aging processes involve effects of steroids on the brain and pituitary. An ovarydependent, neuroendocrine aging syndrome of laboratory rats and mice is described in this article. This syndrome can be attenuated during aging by chronic ovariectomy and can be prematurely induced in young rodents by sustained exposure to estradiol (E2). The limited follicular stock in the ovary is proposed to be a major pacemaker of aging in this neuroendocrine syndrome; ovarian aging may interact with neuroendocrine aging. Ovary-independent neuroendocrine changes occur as well. We also discuss developmental influences on adult aging in rodents and other examples in which adult lower mammals are sensitive to long lasting effects of steroids on the brain and pituitary. Possible molecular mechanisms are considered. In view of the long lasting effects of E2 and other steroids on lower mammals, the potential for long term effects of ovarian steroids on the human brain and pituitary warrants continued evaluation.

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Ovarian and steroidal influences on neuroendocrine aging processes in female rodents

Abstract

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