Outcomes using doxorubicin-based chemotherapy with or without radiotherapy for early-stage peripheral T-cell lymphomas

Hoon K. Lee, Richard B. Wilder, Dan Jones, Chul S. Ha, Barbara Pro, Maria A. Rodriguez, Jorge E. Romaguera, Fernando Cabanillas, Jose Rodriguez, James D. Cox

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

There is little information in the literature on outcomes using doxorubicin-based chemotherapy with or without radiotherapy for early-stage peripheral T-cell lymphomas. The purpose of this study was to analyze The University of Texas M.D. Anderson Cancer Center results in such patients. From 1985 to 1998, 39 patients with Stage I or II World Health Organization classification anaplastic large cell lymphoma (ALCL; n = 20), peripheral T-cell lymphoma, unspecified (PTCLu; n = 11), or nasal-type NK/T-cell lymphoma (NKTCL; n = 8) were treated using doxorubicin-based chemotherapy (median, 6 cycles) with (n = 24) or without (n = 15) radiotherapy (median dose, 40 Gy). Median age was 41 years. Median follow-up of surviving patients was 85 months. Even though patients who presented with bulky disease or who achieved less than a complete response to chemotherapy were the ones typically treated with combined modality therapy rather than chemotherapy alone, there was no significant difference in local control (5-year rates: 60 vs. 70%, p = 0.49), progression-free survival (5-year rates: 65 vs. 60%, p = 0.62), or overall survival (5-year rates: 74 vs. 67%, p = 0.47) between the groups treated with combined modality therapy and chemotherapy alone. Fifteen (38%) patients relapsed. Twelve relapses were limited to the initial site of disease; two involved the initial site and new sites, and one involved only new sites. Based on the significant risk of relapse at the initial site of disease, different approaches, including chemotherapy with concomitant radiotherapy to doses ≥45 Gy, warrant investigation.

Original languageEnglish (US)
Pages (from-to)1769-1775
Number of pages7
JournalLeukemia and Lymphoma
Volume43
Issue number9
DOIs
StatePublished - Aug 23 2002

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Keywords

  • Chemotherapy
  • Prognosis
  • Radiotherapy
  • T-cell lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Lee, H. K., Wilder, R. B., Jones, D., Ha, C. S., Pro, B., Rodriguez, M. A., Romaguera, J. E., Cabanillas, F., Rodriguez, J., & Cox, J. D. (2002). Outcomes using doxorubicin-based chemotherapy with or without radiotherapy for early-stage peripheral T-cell lymphomas. Leukemia and Lymphoma, 43(9), 1769-1775. https://doi.org/10.1080/1042819021000006277