Outcomes of transplantation of single pediatric renal allografts equal to or more than 6 cm in length

Tadahiro Uemura, John Liang, Akhtar Khan, Osun Kwon, Nasrollah Ghahramani, Li Wang, Christopher S. Hollenbeak, William B Reeves, Zakiyah Kadry

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Because of the donor organ shortage, kidneys from smaller pediatric donors are being increasingly used. However, it is unclear whether small pediatric deceased donor kidneys should be used as single grafts or en bloc. We reviewed our outcomes of single kidney transplants from small pediatric donors into adult recipients. Methods: Kidneys equal to or more than 6 cm in length were transplanted as a single kidney in seven adult recipients weighing less than 80 kg. Creatinine clearance, kidney graft size, and glomerular size were followed up at 1, 3, 6, and 12 months after transplantation. Results: All patients and grafts, with the exception of one patient, are currently alive with functional grafts. Two kidneys were procured after cardiac death of the donors, but no delayed graft function was observed. A total of 57% (four of seven) patients developed BK viremia, and 29% (two of seven) patients developed BK virus nephropathy. The graft size significantly increased during follow-up by ultrasonography (P=0.02). The renal allograft function by calculated creatinine clearance also significantly improved at 40.6±6.9 mL/min, 52.7±10.2 mL/min, and 66.2±9.7 mL/min at 1, 3, and 12 month after transplantation, respectively (P=0.01). The size of glomeruli significantly increased from 122±8.4 μm at 1 to 2 months to 169±22.5 μm at 3 to 12 months after transplantation (P<0.01). Conclusions: Kidneys equal to or more than 6 cm from small pediatric donors can be successfully transplanted as a single kidney. Single pediatric kidney transplantation can provide adequate renal function with a speedy increase in allograft size.

Original languageEnglish (US)
Pages (from-to)710-713
Number of pages4
JournalTransplantation
Volume89
Issue number6
DOIs
StatePublished - Mar 1 2010
Externally publishedYes

Fingerprint

Allografts
Transplantation
Pediatrics
Kidney
Tissue Donors
Transplants
Creatinine
BK Virus
Delayed Graft Function
Viremia
Kidney Transplantation
Ultrasonography

Keywords

  • Kidney transplantation
  • Pediatric donor
  • Single pediatric kidney

ASJC Scopus subject areas

  • Transplantation

Cite this

Uemura, T., Liang, J., Khan, A., Kwon, O., Ghahramani, N., Wang, L., ... Kadry, Z. (2010). Outcomes of transplantation of single pediatric renal allografts equal to or more than 6 cm in length. Transplantation, 89(6), 710-713. https://doi.org/10.1097/TP.0b013e3181c90226

Outcomes of transplantation of single pediatric renal allografts equal to or more than 6 cm in length. / Uemura, Tadahiro; Liang, John; Khan, Akhtar; Kwon, Osun; Ghahramani, Nasrollah; Wang, Li; Hollenbeak, Christopher S.; Reeves, William B; Kadry, Zakiyah.

In: Transplantation, Vol. 89, No. 6, 01.03.2010, p. 710-713.

Research output: Contribution to journalArticle

Uemura, T, Liang, J, Khan, A, Kwon, O, Ghahramani, N, Wang, L, Hollenbeak, CS, Reeves, WB & Kadry, Z 2010, 'Outcomes of transplantation of single pediatric renal allografts equal to or more than 6 cm in length', Transplantation, vol. 89, no. 6, pp. 710-713. https://doi.org/10.1097/TP.0b013e3181c90226
Uemura, Tadahiro ; Liang, John ; Khan, Akhtar ; Kwon, Osun ; Ghahramani, Nasrollah ; Wang, Li ; Hollenbeak, Christopher S. ; Reeves, William B ; Kadry, Zakiyah. / Outcomes of transplantation of single pediatric renal allografts equal to or more than 6 cm in length. In: Transplantation. 2010 ; Vol. 89, No. 6. pp. 710-713.
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AU - Liang, John

AU - Khan, Akhtar

AU - Kwon, Osun

AU - Ghahramani, Nasrollah

AU - Wang, Li

AU - Hollenbeak, Christopher S.

AU - Reeves, William B

AU - Kadry, Zakiyah

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N2 - Background: Because of the donor organ shortage, kidneys from smaller pediatric donors are being increasingly used. However, it is unclear whether small pediatric deceased donor kidneys should be used as single grafts or en bloc. We reviewed our outcomes of single kidney transplants from small pediatric donors into adult recipients. Methods: Kidneys equal to or more than 6 cm in length were transplanted as a single kidney in seven adult recipients weighing less than 80 kg. Creatinine clearance, kidney graft size, and glomerular size were followed up at 1, 3, 6, and 12 months after transplantation. Results: All patients and grafts, with the exception of one patient, are currently alive with functional grafts. Two kidneys were procured after cardiac death of the donors, but no delayed graft function was observed. A total of 57% (four of seven) patients developed BK viremia, and 29% (two of seven) patients developed BK virus nephropathy. The graft size significantly increased during follow-up by ultrasonography (P=0.02). The renal allograft function by calculated creatinine clearance also significantly improved at 40.6±6.9 mL/min, 52.7±10.2 mL/min, and 66.2±9.7 mL/min at 1, 3, and 12 month after transplantation, respectively (P=0.01). The size of glomeruli significantly increased from 122±8.4 μm at 1 to 2 months to 169±22.5 μm at 3 to 12 months after transplantation (P<0.01). Conclusions: Kidneys equal to or more than 6 cm from small pediatric donors can be successfully transplanted as a single kidney. Single pediatric kidney transplantation can provide adequate renal function with a speedy increase in allograft size.

AB - Background: Because of the donor organ shortage, kidneys from smaller pediatric donors are being increasingly used. However, it is unclear whether small pediatric deceased donor kidneys should be used as single grafts or en bloc. We reviewed our outcomes of single kidney transplants from small pediatric donors into adult recipients. Methods: Kidneys equal to or more than 6 cm in length were transplanted as a single kidney in seven adult recipients weighing less than 80 kg. Creatinine clearance, kidney graft size, and glomerular size were followed up at 1, 3, 6, and 12 months after transplantation. Results: All patients and grafts, with the exception of one patient, are currently alive with functional grafts. Two kidneys were procured after cardiac death of the donors, but no delayed graft function was observed. A total of 57% (four of seven) patients developed BK viremia, and 29% (two of seven) patients developed BK virus nephropathy. The graft size significantly increased during follow-up by ultrasonography (P=0.02). The renal allograft function by calculated creatinine clearance also significantly improved at 40.6±6.9 mL/min, 52.7±10.2 mL/min, and 66.2±9.7 mL/min at 1, 3, and 12 month after transplantation, respectively (P=0.01). The size of glomeruli significantly increased from 122±8.4 μm at 1 to 2 months to 169±22.5 μm at 3 to 12 months after transplantation (P<0.01). Conclusions: Kidneys equal to or more than 6 cm from small pediatric donors can be successfully transplanted as a single kidney. Single pediatric kidney transplantation can provide adequate renal function with a speedy increase in allograft size.

KW - Kidney transplantation

KW - Pediatric donor

KW - Single pediatric kidney

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