Outcomes from tandem mass spectrometry (MS/MS) workshops in the United States and the performance evaluation of MS/MS laboratories.

Harry Hannon, Timothy Lim, Barbara Adam, Bradford Therrell

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Disorders of fatty acid oxidation and organic acid metabolism produce serious clinical problems including death. Introduction of MS/MS technology for newborn screening allowed detection of these disorders in a single process, more than doubling the number of disorders that can be detected from dried-blood spots in newborn screening. Expanded newborn screening has become a critical issue with increased public awareness and demands. Screening by MS/MS is operational in several private testing and public health laboratories. Guidelines and quality assurance services are essential to enhance program expansions. The first of two workshops was organized in June 2000 and the second in September of 2001 to discuss procedures for integrating MS/MS into newborn screening programs. Both workshops addressed technical problems encountered with implementing MS/MS testing. One outcome of the first workshop was a pilot survey for assessing performance of MS/MS laboratories worldwide, which occurred in September 2000. This pilot survey led to the expansion of the proficiency testing services to include MS/MS testing. There are 32 participating laboratories, three of the ten countries represented are from the Asia-Pacific Region.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalThe Southeast Asian journal of tropical medicine and public health
Volume34 Suppl 3
StatePublished - 2003
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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