Outcome of reintubated patients after scheduled extubation

Fernando Frutos-Vivar, Andrés Esteban, Carlos Apezteguia, Marco González, Yaseen Arabi, Marcos Restrepo, Federico Gordo, Cristina Santos, Jamal A. Alhashemi, Fernando Pérez, Oscar Peñuelas, Antonio R Anzueto

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Purpose: The main objective of study was to evaluate the outcome of patients who require reintubation after elective extubation. Materials and Methods: This is an observational, prospective cohort study including mechanically ventilated patients who passed successfully a spontaneous breathing trial. Patients were observed for 48 hours after extubation. During this time, reintubation or use of noninvasive positive pressure ventilation was considered as a failure. Reintubated patients were followed after the reintubation to register complications and outcome. Results: A total of 1,152 extubated patients were included in the analysis. Three hundred thirty-six patients (29%) met the criteria for extubation failure. Extubation failure was independently associated with mortality (odds ratio, 3.29; 95% confidence interval, 2.19-4.93). One hundred eighty patients (16% of overall cohort) required reintubation within 48 hours after extubation. Median time from extubation to reintubation was 13 hours (interquartile range, 6-24 hours). Reintubation was independently associated with mortality (odds ratio, 5.18; 95% confidence interval, 3.38-7.94; P < .001). Higher mortality of reintubated patients was due to the development of complications after the reintubation. Conclusions: In a large cohort of scheduled extubated patients, one third of patients developed extubation failure, of whom half needed reintubation. Reintubation was associated with increased mortality due to the development of new complications after reintubation.

Original languageEnglish (US)
Pages (from-to)502-509
Number of pages8
JournalJournal of Critical Care
Volume26
Issue number5
DOIs
StatePublished - Oct 2011

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Mortality
Odds Ratio
Confidence Intervals
Positive-Pressure Respiration
Respiration
Cohort Studies
Prospective Studies

Keywords

  • Epidemiology
  • Extubation
  • Noninvasive positive pressure ventilation
  • Outcome
  • Weaning

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Outcome of reintubated patients after scheduled extubation. / Frutos-Vivar, Fernando; Esteban, Andrés; Apezteguia, Carlos; González, Marco; Arabi, Yaseen; Restrepo, Marcos; Gordo, Federico; Santos, Cristina; Alhashemi, Jamal A.; Pérez, Fernando; Peñuelas, Oscar; Anzueto, Antonio R.

In: Journal of Critical Care, Vol. 26, No. 5, 10.2011, p. 502-509.

Research output: Contribution to journalArticle

Frutos-Vivar, F, Esteban, A, Apezteguia, C, González, M, Arabi, Y, Restrepo, M, Gordo, F, Santos, C, Alhashemi, JA, Pérez, F, Peñuelas, O & Anzueto, AR 2011, 'Outcome of reintubated patients after scheduled extubation', Journal of Critical Care, vol. 26, no. 5, pp. 502-509. https://doi.org/10.1016/j.jcrc.2010.12.015
Frutos-Vivar F, Esteban A, Apezteguia C, González M, Arabi Y, Restrepo M et al. Outcome of reintubated patients after scheduled extubation. Journal of Critical Care. 2011 Oct;26(5):502-509. https://doi.org/10.1016/j.jcrc.2010.12.015
Frutos-Vivar, Fernando ; Esteban, Andrés ; Apezteguia, Carlos ; González, Marco ; Arabi, Yaseen ; Restrepo, Marcos ; Gordo, Federico ; Santos, Cristina ; Alhashemi, Jamal A. ; Pérez, Fernando ; Peñuelas, Oscar ; Anzueto, Antonio R. / Outcome of reintubated patients after scheduled extubation. In: Journal of Critical Care. 2011 ; Vol. 26, No. 5. pp. 502-509.
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AU - Arabi, Yaseen

AU - Restrepo, Marcos

AU - Gordo, Federico

AU - Santos, Cristina

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AU - Pérez, Fernando

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KW - Weaning

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