Other important applications for beta-blockers in high-risk patients.

Brent M. Egan, Robert J. Chilton

Research output: Contribution to journalArticlepeer-review


Beta-blockers suppress the adverse effects of chronic activation of the sympathetic nervous system-which plays an important role in the progression of cardiovascular disease- and the drugs are also recommended as primary therapy in other diverse medical conditions that present treatment problems. For many patients with atrial fibrillation, a common condition that poses a high risk of stroke, heart rate control with beta-blockers is increasingly seen as a critical therapeutic component. Similarly, perioperative beta-blocker use provides clinical benefits in patients undergoing noncardiac surgery who are at risk of cardiac events. In migraine therapy, beta-blockers are well established as effective agents for prophylaxis, and beta-blockers may reduce levels of C-reactive protein, a sensitive marker of inflammation in cardiovascular disease. Reviewing the role of beta-blockers in several ancillary conditions should help illuminate various aspects of the complex progression of cardiovascular disease and clarify the drugs' various therapeutic benefits.

Original languageEnglish (US)
Pages (from-to)35-48
Number of pages14
JournalPostgraduate medicine
Issue number6 Suppl Role
StatePublished - Dec 2003
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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