TY - GEN
T1 - Osteogain™ enhances the osteoinductive potential of demineralized bone matrix
AU - Harrington, Maya
AU - Cohen, David J.
AU - Boyan, Barbara D.
AU - Schwartz, Zvi
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Orthopedic and dental treatment commonly uses bone grafts to fill bone defects, facilitate bone repair, provide mechanical support, and stabilize a deformed area during bone regeneration. In combination with the bone grafting material, growth factors and proteins are used to enhance osteogenesis during bone regeneration. One of these bone-enhancing proteins is provided in enamel matrix derivative (EMD). Osteogain™ is a liquid formulation of EMD, which has been found to enhance periodontal regeneration in vivo and improve osteogenic differentiation of bone cells in vitro. It is not clear if combining Osteogain™ with bone grafting materials like demineralized bone matrix (DBM) will increase their osteoinductive potential. The liquid carrier system is promising because it provides increased surface loading for porous graft materials and allows more stable proteins surface coatings. The objective of this study was to determine whether Osteogain™ can increase the osteoinductive potential of DBM in vivo in an established mouse model of bone induction.
AB - Orthopedic and dental treatment commonly uses bone grafts to fill bone defects, facilitate bone repair, provide mechanical support, and stabilize a deformed area during bone regeneration. In combination with the bone grafting material, growth factors and proteins are used to enhance osteogenesis during bone regeneration. One of these bone-enhancing proteins is provided in enamel matrix derivative (EMD). Osteogain™ is a liquid formulation of EMD, which has been found to enhance periodontal regeneration in vivo and improve osteogenic differentiation of bone cells in vitro. It is not clear if combining Osteogain™ with bone grafting materials like demineralized bone matrix (DBM) will increase their osteoinductive potential. The liquid carrier system is promising because it provides increased surface loading for porous graft materials and allows more stable proteins surface coatings. The objective of this study was to determine whether Osteogain™ can increase the osteoinductive potential of DBM in vivo in an established mouse model of bone induction.
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M3 - Conference contribution
AN - SCOPUS:85065396666
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -