Osteogain™ enhances the osteoinductive potential of demineralized bone matrix

Maya Harrington, David J. Cohen, Barbara D. Boyan, Zvi Schwartz

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Orthopedic and dental treatment commonly uses bone grafts to fill bone defects, facilitate bone repair, provide mechanical support, and stabilize a deformed area during bone regeneration. In combination with the bone grafting material, growth factors and proteins are used to enhance osteogenesis during bone regeneration. One of these bone-enhancing proteins is provided in enamel matrix derivative (EMD). Osteogain™ is a liquid formulation of EMD, which has been found to enhance periodontal regeneration in vivo and improve osteogenic differentiation of bone cells in vitro. It is not clear if combining Osteogain™ with bone grafting materials like demineralized bone matrix (DBM) will increase their osteoinductive potential. The liquid carrier system is promising because it provides increased surface loading for porous graft materials and allows more stable proteins surface coatings. The objective of this study was to determine whether Osteogain™ can increase the osteoinductive potential of DBM in vivo in an established mouse model of bone induction.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019 → Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/19 → 4/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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    Harrington, M., Cohen, D. J., Boyan, B. D., & Schwartz, Z. (2019). Osteogain™ enhances the osteoinductive potential of demineralized bone matrix. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.