Osteochondrosis in fetuses of ewes overfed calcium

Carlos N. Corbellini, Lennart Krook, Peter W. Nathanielsz, Francis A. Kallfelz

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Ewes were fed ad libitum (up to maximum of 2.5 kg/day) a complete feed containing either 1.52% calcium (High Ca) or 0.59% calcium (Normal Ca) on a dry matter basis from day 50 of pregnancy, and the fetuses were removed at 133-135 days. Thyroid C cells, identified by indirect immunofluorescence, were more numerous (P<0.001) and plasma levels of 24,25-dihydroxycholecalciferol [24,25(OH)2D] were higher (P<0.09) in fetuses of High Ca ewes. These fetuses also had retarded cartilage differentiation in the proximal humeral epiphysis and metaphysis as well as transverse trabeculation in the epiphysis. These entities are two of the hallmarks of osteochondrosis. It was shown that feeding high dietary calcium to pregnant ewes caused osteochondrosis in their fetuses. Hypercalcitoninism and/or an adverse effect of supraphysiological levels of 24,25-dihydroxycholecalciferol may have been contributory to the skeletal abnormalities.

Original languageEnglish (US)
Pages (from-to)37-45
Number of pages9
JournalCalcified tissue international
Issue number1
StatePublished - Jan 1 1991
Externally publishedYes


  • 24,25-dihydroxyvitamin D
  • Hypercalcitoninism
  • Osteochondrosis
  • Ovine fetuses

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology


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