Orthostatic effect of imipramine and doxepin in depressed geriatric outpatients

Robert E. Neshkes, Robert Gerner, Lissy F. Jarvik, Jim Mintz, Jeffrey Joseph, Shirley Linde, Jeanne Aldrich, Matthew E. Conolly, Richard Rosen, Maryann Hill

Research output: Contribution to journalArticle

21 Scopus citations


Blood pressure measurements were collected from 36 depressed geriatric outpatients (ages 55 to 81 years) enrolled in a double-blind, placebocontrolled study of the efficacy of doxepin and imipramine. Mean systolic postural changes were 25.9 mm Hg for imipramine, significantly higher than the 10.5 mm Hg for doxepin, and 12.4 mm Hg for placebo. The orthostatic drop in the imipramine group was only weakly related to dose and did not correlate with amount of pretreatment orthostatic hypotension or with duration of treatment. The increased orthostatic hypotension occurred early in treatment and at low doses of imipramine. Accordingly, caution is advised in the use of imipramine for the elderly.

Original languageEnglish (US)
Pages (from-to)102-106
Number of pages5
JournalJournal of Clinical Psychopharmacology
Issue number2
StatePublished - Apr 1985


ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Neshkes, R. E., Gerner, R., Jarvik, L. F., Mintz, J., Joseph, J., Linde, S., Aldrich, J., Conolly, M. E., Rosen, R., & Hill, M. (1985). Orthostatic effect of imipramine and doxepin in depressed geriatric outpatients. Journal of Clinical Psychopharmacology, 5(2), 102-106.