Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas

Rebeca Rico-Hesse, Lisa M. Harrison, Rosa Alba Salas, Duilia Tovar, Ananda Nisalak, Celso Ramos, Jorge Boshell, Maria Teresa R. De Mesa, Rita M.R. Nogueira, Amélia Travassos Da Rosa

    Research output: Contribution to journalArticlepeer-review

    484 Scopus citations

    Abstract

    The recent emergence and spread of dengue hemorrhagic fever in the Americas have been a major source of concern. Efforts to control this disease are dependent on understanding the pathogenicity of dengue viruses and their transmission dynamics. Pathogenicity studies have been hampered by the lack of in vitro or in vivo models of severe dengue disease. Alternatively, molecular epidemiologic studies which associate certain dengue virus genetic types with severe dengue outbreaks may point to strains with increased pathogenicity. The comparison of nucleotide sequences (240 bp) from the E/NS1 gene region of the dengue virus genome has been shown to reflect evolutionary relationships and geographic origins of dengue virus strains. This approach was used to demonstrate an association between the introduction of two distinct genotypes of dengue type 2 virus and the appearance of dengue hemorrhagic fever in the Americas. Phylogenetic analyses suggest that these genotypes originated in Southeast Asia and that they displaced the native, American genotype in at least four countries. Vaccination and other control efforts should therefore be directed at decreasing the transmission of these 'virulent' genotypes.

    Original languageEnglish (US)
    Pages (from-to)244-251
    Number of pages8
    JournalVirology
    Volume230
    Issue number2
    DOIs
    StatePublished - Apr 14 1997

    ASJC Scopus subject areas

    • Virology

    Fingerprint Dive into the research topics of 'Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas'. Together they form a unique fingerprint.

    Cite this