Organ failure, infection, and the systemic inflammatory response syndrome are associated with elevated levels of urinary intestinal fatty acid binding protein: Study of 100 consecutive patients in a surgical intensive care unit

Joshua M. Lieberman, William H. Marks, Stephen Cohn, Russell Jaicks, Lawrence Woode, James Sacchettini, Brian Fischer, Beth Moller, Gerard Burns

Research output: Contribution to journalArticle

33 Scopus citations


Background: Intestinal mucosal ischemia and subsequent barrier dysfunction have been related to the development of organ dysfunction and death in the critically ill. We hypothesized that urine concentrations of intestinal fatty acid binding protein (IFABP), a sensitive marker of intestinal ischemia, might predict the development of the systemic inflammatory response syndrome (SIRS) and organ dysfunction. Methods: One hundred consecutive critically ill patients were prospectively studied for the development of infectious complications, organ dysfunction, and SIRS. Urine was collected daily for measurement of IFABP. Results: A total of 58 males and 42 females (mean age, 56 years; range, 16-85 years) were studied. Of these 100 patients, 40 patients developed complications and 5 patients developed SIRS. IFABP was significantly elevated in all patients with SIRS, and IFABP levels peaked an average of 1.4 days (range, 0-7 days) before the diagnosis of SIRS. Conclusion: Elevated concentrations of urine IFABP correlated with the clinical development of SIRS. Studies to assess the utility of IFABP as a predictor of organ dysfunction and SIRS in the critically ill are warranted.

Original languageEnglish (US)
Pages (from-to)900-906
Number of pages7
JournalJournal of Trauma - Injury, Infection and Critical Care
Issue number5
StatePublished - Nov 1998


ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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