TY - JOUR
T1 - Orally administered melatonin reduces oxidative stress and proinflammatory cytokines induced by amyloid-β peptide in rat brain
T2 - A comparative, in vivo study versus vitamin C and E
AU - Rosales-Corral, Sergio
AU - Tan, Dun Xian
AU - Reiter, Russel J.
AU - Valdivia-Velázquez, Miguel
AU - Martínez-Barboza, Gabriela
AU - Acosta-Martínez, J. Pablo
AU - Ortiz, Genaro G.
PY - 2003/9
Y1 - 2003/9
N2 - To determine the efficacy of antioxidants in reducing amyloid-β-induced oxidative stress, and the neuroinflammatory response in the central nervous system (CNS) in vivo, three injections of fibrillar amyloid-β (fAβ) or artificial cerebrospinal fluid (aCSF) into the CA1 region of the hippocampus of the rat were made. Concomitantly, one of the three free radical scavengers, i.e. melatonin, vitamin C, or vitamin E was also administered. Besides being a free radical scavenger, melatonin also has immunomodulatory functions. Antioxidant treatment reduced significantly oxidative stress and pro-inflammatory cytokines. There were no marked differences between melatonin, vitamin C, and vitamin E regarding their capacity to reduce nitrites and lipoperoxides. However, melatonin exhibited a superior capacity to reduce the pro-inflammatory response induced by fAβ.
AB - To determine the efficacy of antioxidants in reducing amyloid-β-induced oxidative stress, and the neuroinflammatory response in the central nervous system (CNS) in vivo, three injections of fibrillar amyloid-β (fAβ) or artificial cerebrospinal fluid (aCSF) into the CA1 region of the hippocampus of the rat were made. Concomitantly, one of the three free radical scavengers, i.e. melatonin, vitamin C, or vitamin E was also administered. Besides being a free radical scavenger, melatonin also has immunomodulatory functions. Antioxidant treatment reduced significantly oxidative stress and pro-inflammatory cytokines. There were no marked differences between melatonin, vitamin C, and vitamin E regarding their capacity to reduce nitrites and lipoperoxides. However, melatonin exhibited a superior capacity to reduce the pro-inflammatory response induced by fAβ.
KW - Amyloid-β
KW - Antioxidants
KW - Melatonin
KW - Neuroinflammatory cytokines
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=0043091912&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0043091912&partnerID=8YFLogxK
U2 - 10.1034/j.1600-079X.2003.00057.x
DO - 10.1034/j.1600-079X.2003.00057.x
M3 - Article
C2 - 12887649
AN - SCOPUS:0043091912
SN - 0742-3098
VL - 35
SP - 80
EP - 84
JO - Journal of pineal research
JF - Journal of pineal research
IS - 2
ER -