Orally administered melatonin reduces oxidative stress and proinflammatory cytokines induced by amyloid-β peptide in rat brain: A comparative, in vivo study versus vitamin C and E

Sergio Rosales-Corral, Dun Xian Tan, Russel J. Reiter, Miguel Valdivia-Velázquez, Gabriela Martínez-Barboza, J. Pablo Acosta-Martínez, Genaro G. Ortiz

Research output: Contribution to journalArticlepeer-review

94 Scopus citations

Abstract

To determine the efficacy of antioxidants in reducing amyloid-β-induced oxidative stress, and the neuroinflammatory response in the central nervous system (CNS) in vivo, three injections of fibrillar amyloid-β (fAβ) or artificial cerebrospinal fluid (aCSF) into the CA1 region of the hippocampus of the rat were made. Concomitantly, one of the three free radical scavengers, i.e. melatonin, vitamin C, or vitamin E was also administered. Besides being a free radical scavenger, melatonin also has immunomodulatory functions. Antioxidant treatment reduced significantly oxidative stress and pro-inflammatory cytokines. There were no marked differences between melatonin, vitamin C, and vitamin E regarding their capacity to reduce nitrites and lipoperoxides. However, melatonin exhibited a superior capacity to reduce the pro-inflammatory response induced by fAβ.

Original languageEnglish (US)
Pages (from-to)80-84
Number of pages5
JournalJournal of pineal research
Volume35
Issue number2
DOIs
StatePublished - Sep 2003

Keywords

  • Amyloid-β
  • Antioxidants
  • Melatonin
  • Neuroinflammatory cytokines
  • Oxidative stress

ASJC Scopus subject areas

  • Endocrinology

Fingerprint

Dive into the research topics of 'Orally administered melatonin reduces oxidative stress and proinflammatory cytokines induced by amyloid-β peptide in rat brain: A comparative, in vivo study versus vitamin C and E'. Together they form a unique fingerprint.

Cite this