Oral vaccination of racoons (Procyon lotor) with baculovirus-expressed rabies virus glycoprotein

Zhen Fang Fu, Charles E. Rupprecht, Bernhard Dietzschold, Potham Saikumar, Hong Shun Niu, Ildiko Babka, William H. Wunner, Hilary Koprowski

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Successful field oral vaccination and protection against viral diseases have so far been achieved only with live-attenuated or live-recombinant virus vaccines. In this communication, we present data that demonstrate that a glycoprotein derived from recombinant baculovirus-infected insect cells is efficacious as an oral vaccine. The glycoprotein (G) of rabies virus (Evelyn Rokitnicki Abelseth strain) was abundantly expressed in a baculovirus expression system and oral vaccination of racoons with the baculovirus-expressed G protein resulted in the production of rabies virus-neutralizing antibodies and protection against a lethal challenge with a street rabies virus. The potential for using the baculovirus-expressed G protein for oral immunization of wildlife is discussed.

Original languageEnglish (US)
Pages (from-to)925-928
Number of pages4
Issue number9
StatePublished - 1993
Externally publishedYes


  • Rabies
  • baculovirus
  • glycoprotein
  • oral vaccination
  • wildlife

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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