Oral ingestion of Ginkgo biloba extract reduces thiobarbituric acid reacting (TBAR) substances in washed platelets of healthy subjects

George B. Kudolo, Wen Wang, Sheryl Dorsey, Janet Blodgett

Research output: Contribution to journalArticle

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Abstract

Thiobarbituric acid reacting (TBAR) substances were measured in washed platelets before and after ingesting 120 mg of standardized Ginkgo biloba extract daily for 3 months, in both normocholesterolemic (total cholesterol, 160 ± 27 mg/dl; age, 40 ± 13 years; n = 18) and hypercholesterolemic subjects (total cholesterol, 229 ± 35; age, 45 ± 8 years; n = 12). Ginkgo biloba extract significantly reduced cellular content of TBAR substances; 42 ± 21 vs. 28 ± 16 pmol/107 platelets (p < 0.0025) and 50 ± 17 vs. 29 ± 13 pmol/107 platelets (p < 0.004), for the normo- and hypercholemic subjects, respectively. In conclusion, Ginkgo biloba extract is a potent antioxidant in both groups, reducing TBAR substances possibly by inhibiting platelet COX-1 isoform activity.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalJournal of Herbal Pharmacotherapy
Volume3
Issue number4
DOIs
Publication statusPublished - Dec 1 2003

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Keywords

  • Free radical scavengers
  • Ginkgo biloba
  • Malondialdehyde
  • Platelets

ASJC Scopus subject areas

  • Pharmacology

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