Oral hygiene regimens, plaque control, and gingival health: A two-month clinical trial with antimicrobial agents

Aaron R. Biesbrock, Robert D. Bartizek, Robert W. Gerlach, Géza T. Terézhalmy

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Objective: The purpose of this study was to examine the effects of various product combinations involving brush, paste, rinse, and floss on the prevention of plaque regrowth and gingivitis. Methodology: In this randomized, parallel-group, examiner-blind, eight-week study, 179 subjects with gingivitis had a dental prophylaxis and were randomly assigned to one of six product combinations: 1) Colgate® Wave manual toothbrush + Colgate® Total® dentifrice (0.3% triclosan/copolymer dentifrice); 2) Wave + Total + Listerine® (essential oils rinse); 3) Oral-B® CrossAction® manual toothbrush + Crest® Pro-Health™ dentifrice (0.454% stannous fluoride/sodium hexametaphosphate); 4) CrossAction + Pro-Health dentifrice + Crest® Pro-Health™ Rinse (0.07% cetylpyridinium chloride rinse); 5) Oral-B® ProfessionalCare® Series 8000 power toothbrush + Pro-Health dentifrice; or 6) ProfessionalCare power brush 4- Pro-Health dentifrice + Oral-B® Hummingbird® power flosser. Subjects used their test products for the duration of the study. Whole mouth plaque, gingivitis, and product-related adverse events were assessed. Treatments were compared at a 0.05 level of significance. Results: One-hundred and seventy-four subjects completed the study and were included in the data analysis. At Week 8, the overnight adjusted whole mouth plaque scores were statistically significantly lower in all other groups relative to the Wave + Total group (p ≤: 0.030). Plaque scores were also statistically significantly lower (∼ 20%) in both groups where a therapeutic rinse was added to a manual brush and therapeutic paste relative to scores for the brush plus paste without a rinse (p ≤ 0.034). All groups showed a reduction in gingivitis at Week 4, and mean scores remained stable or increased slightly at Week 8. The power toothbrush groups were directionally better at preventing gingivitis than the manual groups at Weeks 4 and 8. Conclusion: Reductions in overnight plaque were seen when therapeutic rinses were added to manual brush plus therapeutic dentifrice regimens above that observed with a manual brush and therapeutic dentifrice alone.

Original languageEnglish (US)
Pages (from-to)101-105
Number of pages5
JournalJournal of Clinical Dentistry
Issue number4
StatePublished - Dec 1 2007

ASJC Scopus subject areas

  • Dentistry(all)


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