TY - JOUR
T1 - Oral administration of melatonin to old ring doves (Streptopelia risoria) increases plasma levels of melatonin and heterophil phagocytic activity
AU - Terrón, Ma Del Pilar
AU - Paredes, Sergio D.
AU - Barriga, Carmen
AU - Ortega, Eduarde
AU - Reiter, Russel J.
AU - Rodríguez, Ana B.
N1 - Funding Information:
ACKNOWLEDGMENTS This investigation was supported by a research grant from the Ministerio de Ciencia y Tecnología (BFI2002-04583-C02-01). During the performance of this work, M.P.T. and S.D.P. were supported by a personal researcher training grant from the Consejería de Educación, Ciencia y Tecnología / Fondo Social Europeo (Junta de Extremadura, FIC00B013 and FIC02A049, respectively). The authors would like to express their thanks to Ms Elena Circujano Vadillo for her technical assistance.
PY - 2005/1
Y1 - 2005/1
N2 - We analyzed the effect of oral melatonin (23 μg/0.1 ml/animal/d; 1 h before dark on 12 consecutive days) in old birds, in natural photoperiods, on the hormone's plasma levels, and phagocytosis. Blood collections were performed daily at 2:00 AM and 4:00 PM until 5 days after the treatment. From day 1, the melatonin levels were significantly higher than basal levels at both times. Values at 2:00 AM were significantly higher than the 4:00 PM values. After treatment, the melatonin levels declined, returning from day 14 to basal values at both hours. At 2:00 AM. phagocytosis was significantly greater than that obtained at 4:00 PM and greater than basal values. The 4:00 PM values were only significantly greater than basal on days 6 and 8, parallel to a decline in Superoxide anion levels, which were lowest at 2:00 AM. Melatonin administered to old ring doves increases the differences between nocturnal and diurnal plasma levels, and, in parallel, increases phagocytosis and reduces Superoxide radical levels in heterophils.
AB - We analyzed the effect of oral melatonin (23 μg/0.1 ml/animal/d; 1 h before dark on 12 consecutive days) in old birds, in natural photoperiods, on the hormone's plasma levels, and phagocytosis. Blood collections were performed daily at 2:00 AM and 4:00 PM until 5 days after the treatment. From day 1, the melatonin levels were significantly higher than basal levels at both times. Values at 2:00 AM were significantly higher than the 4:00 PM values. After treatment, the melatonin levels declined, returning from day 14 to basal values at both hours. At 2:00 AM. phagocytosis was significantly greater than that obtained at 4:00 PM and greater than basal values. The 4:00 PM values were only significantly greater than basal on days 6 and 8, parallel to a decline in Superoxide anion levels, which were lowest at 2:00 AM. Melatonin administered to old ring doves increases the differences between nocturnal and diurnal plasma levels, and, in parallel, increases phagocytosis and reduces Superoxide radical levels in heterophils.
UR - http://www.scopus.com/inward/record.url?scp=14644429039&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14644429039&partnerID=8YFLogxK
U2 - 10.1093/gerona/60.1.44
DO - 10.1093/gerona/60.1.44
M3 - Article
C2 - 15741282
AN - SCOPUS:14644429039
VL - 60
SP - 44
EP - 50
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
SN - 1079-5006
IS - 1
ER -