Abstract
We analyzed the effect of oral melatonin (23 μg/0.1 ml/animal/d; 1 h before dark on 12 consecutive days) in old birds, in natural photoperiods, on the hormone's plasma levels, and phagocytosis. Blood collections were performed daily at 2:00 AM and 4:00 PM until 5 days after the treatment. From day 1, the melatonin levels were significantly higher than basal levels at both times. Values at 2:00 AM were significantly higher than the 4:00 PM values. After treatment, the melatonin levels declined, returning from day 14 to basal values at both hours. At 2:00 AM. phagocytosis was significantly greater than that obtained at 4:00 PM and greater than basal values. The 4:00 PM values were only significantly greater than basal on days 6 and 8, parallel to a decline in Superoxide anion levels, which were lowest at 2:00 AM. Melatonin administered to old ring doves increases the differences between nocturnal and diurnal plasma levels, and, in parallel, increases phagocytosis and reduces Superoxide radical levels in heterophils.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 44-50 |
| Number of pages | 7 |
| Journal | Journals of Gerontology - Series A Biological Sciences and Medical Sciences |
| Volume | 60 |
| Issue number | 1 |
| State | Published - Jan 2005 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Aging
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Oral administration of melatonin to old ring doves (Streptopelia risoria) increases plasma levels of melatonin and heterophil phagocytic activity. / Terrón, Ma Del Pilar; Paredes, Sergio D.; Barriga, Carmen; Ortega, Eduarde; Reiter, Russel J; Rodríguez, Ana B.
In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 60, No. 1, 01.2005, p. 44-50.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oral administration of melatonin to old ring doves (Streptopelia risoria) increases plasma levels of melatonin and heterophil phagocytic activity
AU - Terrón, Ma Del Pilar
AU - Paredes, Sergio D.
AU - Barriga, Carmen
AU - Ortega, Eduarde
AU - Reiter, Russel J
AU - Rodríguez, Ana B.
PY - 2005/1
Y1 - 2005/1
N2 - We analyzed the effect of oral melatonin (23 μg/0.1 ml/animal/d; 1 h before dark on 12 consecutive days) in old birds, in natural photoperiods, on the hormone's plasma levels, and phagocytosis. Blood collections were performed daily at 2:00 AM and 4:00 PM until 5 days after the treatment. From day 1, the melatonin levels were significantly higher than basal levels at both times. Values at 2:00 AM were significantly higher than the 4:00 PM values. After treatment, the melatonin levels declined, returning from day 14 to basal values at both hours. At 2:00 AM. phagocytosis was significantly greater than that obtained at 4:00 PM and greater than basal values. The 4:00 PM values were only significantly greater than basal on days 6 and 8, parallel to a decline in Superoxide anion levels, which were lowest at 2:00 AM. Melatonin administered to old ring doves increases the differences between nocturnal and diurnal plasma levels, and, in parallel, increases phagocytosis and reduces Superoxide radical levels in heterophils.
AB - We analyzed the effect of oral melatonin (23 μg/0.1 ml/animal/d; 1 h before dark on 12 consecutive days) in old birds, in natural photoperiods, on the hormone's plasma levels, and phagocytosis. Blood collections were performed daily at 2:00 AM and 4:00 PM until 5 days after the treatment. From day 1, the melatonin levels were significantly higher than basal levels at both times. Values at 2:00 AM were significantly higher than the 4:00 PM values. After treatment, the melatonin levels declined, returning from day 14 to basal values at both hours. At 2:00 AM. phagocytosis was significantly greater than that obtained at 4:00 PM and greater than basal values. The 4:00 PM values were only significantly greater than basal on days 6 and 8, parallel to a decline in Superoxide anion levels, which were lowest at 2:00 AM. Melatonin administered to old ring doves increases the differences between nocturnal and diurnal plasma levels, and, in parallel, increases phagocytosis and reduces Superoxide radical levels in heterophils.
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UR - http://www.scopus.com/inward/citedby.url?scp=14644429039&partnerID=8YFLogxK
M3 - Article
C2 - 15741282
AN - SCOPUS:14644429039
VL - 60
SP - 44
EP - 50
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
SN - 1079-5006
IS - 1
ER -