Opto-acoustic image fusion technology for diagnostic breast imaging in a feasibility study

Jason Zalev; Bryan Clingman; Don Herzog; Tom Miller; Michael Ulissey; A. T. Stavros; Alexander Oraevsky; Philip Lavin; Kenneth Kist; N. C. Dornbluth; Pamela Otto

doi:10.1117/12.2081679

Opto-acoustic image fusion technology for diagnostic breast imaging in a feasibility study

Jason Zalev, Bryan Clingman, Don Herzog, Tom Miller, Michael Ulissey, A. T. Stavros, Alexander Oraevsky, Philip Lavin, Kenneth Kist, N. C. Dornbluth, Pamela Otto

Radiology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

11 Scopus citations

Abstract

Functional opto-acoustic (OA) imaging was fused with gray-scale ultrasound acquired using a specialized duplex handheld probe. Feasibility Study findings indicated the potential to more accurately characterize breast masses for cancer than conventional diagnostic ultrasound (CDU). The Feasibility Study included OA imagery of 74 breast masses that were collected using the investigational Imagio® breast imaging system. Superior specificity and equal sensitivity to CDU was demonstrated, suggesting that OA fusion imaging may potentially obviate the need for negative biopsies without missing cancers in a certain percentage of breast masses. Preliminary results from a 100 subject Pilot Study are also discussed. A larger Pivotal Study (n=2,097 subjects) is underway to confirm the Feasibility Study and Pilot Study findings.

Original language	English (US)
Title of host publication	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Publisher	SPIE
Volume	9419
ISBN (Print)	9781628415094
DOIs	https://doi.org/10.1117/12.2081679
State	Published - 2015
Event	Medical Imaging 2015: Ultrasonic Imaging and Tomography - Orlando, United States Duration: Feb 22 2015 → Feb 23 2015

Other

Other	Medical Imaging 2015: Ultrasonic Imaging and Tomography
Country/Territory	United States
City	Orlando
Period	2/22/15 → 2/23/15

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Biomaterials
Radiology Nuclear Medicine and imaging

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10.1117/12.2081679

Cite this

Zalev, J., Clingman, B., Herzog, D., Miller, T., Ulissey, M., Stavros, A. T., Oraevsky, A., Lavin, P., Kist, K., Dornbluth, N. C., & Otto, P. (2015). Opto-acoustic image fusion technology for diagnostic breast imaging in a feasibility study. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9419). [941909] SPIE. https://doi.org/10.1117/12.2081679

Opto-acoustic image fusion technology for diagnostic breast imaging in a feasibility study. / Zalev, Jason; Clingman, Bryan; Herzog, Don; Miller, Tom; Ulissey, Michael; Stavros, A. T.; Oraevsky, Alexander; Lavin, Philip; Kist, Kenneth; Dornbluth, N. C.; Otto, Pamela.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9419 SPIE, 2015. 941909.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Zalev, J, Clingman, B, Herzog, D, Miller, T, Ulissey, M, Stavros, AT, Oraevsky, A, Lavin, P, Kist, K, Dornbluth, NC & Otto, P 2015, Opto-acoustic image fusion technology for diagnostic breast imaging in a feasibility study. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 9419, 941909, SPIE, Medical Imaging 2015: Ultrasonic Imaging and Tomography, Orlando, United States, 2/22/15. https://doi.org/10.1117/12.2081679

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abstract = "Functional opto-acoustic (OA) imaging was fused with gray-scale ultrasound acquired using a specialized duplex handheld probe. Feasibility Study findings indicated the potential to more accurately characterize breast masses for cancer than conventional diagnostic ultrasound (CDU). The Feasibility Study included OA imagery of 74 breast masses that were collected using the investigational Imagio{\textregistered} breast imaging system. Superior specificity and equal sensitivity to CDU was demonstrated, suggesting that OA fusion imaging may potentially obviate the need for negative biopsies without missing cancers in a certain percentage of breast masses. Preliminary results from a 100 subject Pilot Study are also discussed. A larger Pivotal Study (n=2,097 subjects) is underway to confirm the Feasibility Study and Pilot Study findings.",

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AU - Miller, Tom

AU - Ulissey, Michael

AU - Stavros, A. T.

AU - Oraevsky, Alexander

AU - Lavin, Philip

AU - Kist, Kenneth

AU - Dornbluth, N. C.

AU - Otto, Pamela

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AB - Functional opto-acoustic (OA) imaging was fused with gray-scale ultrasound acquired using a specialized duplex handheld probe. Feasibility Study findings indicated the potential to more accurately characterize breast masses for cancer than conventional diagnostic ultrasound (CDU). The Feasibility Study included OA imagery of 74 breast masses that were collected using the investigational Imagio® breast imaging system. Superior specificity and equal sensitivity to CDU was demonstrated, suggesting that OA fusion imaging may potentially obviate the need for negative biopsies without missing cancers in a certain percentage of breast masses. Preliminary results from a 100 subject Pilot Study are also discussed. A larger Pivotal Study (n=2,097 subjects) is underway to confirm the Feasibility Study and Pilot Study findings.

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Opto-acoustic image fusion technology for diagnostic breast imaging in a feasibility study

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