Optimizing human demineralized bone matrix for clinical application

E. Maddox, M. Zhan, G. R. Mundy, W. N. Drohan, W. H. Burgess

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


The use of human demineralized bone matrix (DBM) powder in periodontal and orthopedic applications is limited by the variability in the osteoinductive or osteoconductive properties of the material. The goal of the present study was to establish simple in vitro and in vivo assays of DBM that would allow us to screen different lots of the material prior to testing in more rigorous animal models. The results demonstrate a wide variability in the performance of individual lots of DBM powder obtained from a single tissue bank. The studies also demonstrate that relatively simple screening can be used to establish the quality of the different lots, and that performance and ease of handling can be improved by using relatively small particle sizes delivered in a fibrin sealant matrix.

Original languageEnglish (US)
Pages (from-to)441-448
Number of pages8
JournalTissue Engineering
Issue number4
StatePublished - 2000

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Cell Biology


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