TY - GEN
T1 - Optimization of drug release profile from pegylated polyvinylidene fluoride-polypyrrole core-shell electrospun mesh
AU - Miar, Solaleh
AU - Acosta, Francisca
AU - Guda, Teja
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: Muscle regeneration requires electromechanical stimuli as well as biochemical growth factors[1] to guide differentiation into functional muscle. Smart growth factor release is a big challenge in tissue engineering since different growth factors should be released at different times to be effective[2]. In this research, we designed a scaffold with the ability to not only direct satellite cells to grow aligned on the fibers but to also release growth factors under applied electrical stimulation to benefit both cell differentiation and the drug release. We used the streptavidin as a drug carrier in a synthetic PEGylated Polyvinylidene Fluoride-Polypyrrole Core-Shell electrospun mesh. We have also evaluated the impact of the saturation of streptavidin with the drug which changes the bioavailability of the model drug (insulin like growth factor) allowing tuning of the control release system and drug effectiveness.
AB - Statement of Purpose: Muscle regeneration requires electromechanical stimuli as well as biochemical growth factors[1] to guide differentiation into functional muscle. Smart growth factor release is a big challenge in tissue engineering since different growth factors should be released at different times to be effective[2]. In this research, we designed a scaffold with the ability to not only direct satellite cells to grow aligned on the fibers but to also release growth factors under applied electrical stimulation to benefit both cell differentiation and the drug release. We used the streptavidin as a drug carrier in a synthetic PEGylated Polyvinylidene Fluoride-Polypyrrole Core-Shell electrospun mesh. We have also evaluated the impact of the saturation of streptavidin with the drug which changes the bioavailability of the model drug (insulin like growth factor) allowing tuning of the control release system and drug effectiveness.
UR - https://www.scopus.com/pages/publications/85065403371
UR - https://www.scopus.com/pages/publications/85065403371#tab=citedBy
M3 - Conference contribution
AN - SCOPUS:85065403371
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 794
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -