Optical diagnostics based on elastic scattering: Recent clinical demonstrations with the los alamos optical biopsy system

Irving J. Bigio, Thomas R. Loree, Judith Mourant, Tsutomu Shimada, K. Story-Held, R. D. Glickman, Richard Conn

Research output: Contribution to journalConference article

7 Scopus citations

Abstract

A non-invasive diagnostic tool that could identify malignancy in situ and in real time would have a major impact on the detection and treatment of cancer. We have developed and are testing early prototypes of an optical biopsy system (OBS) for detection of cancer and other tissue pathologies. The OBS invokes a unique approach to optical diagnosis of tissue pathologies based on the elastic scattering properties, over a wide range of wavelengths, of the microscopic structure of the tissue. The use of elastic scattering as the key to optical tissue diagnostics in the OBS is based on the fact that many tissue pathologies, including a majority of cancer forms, manifest significant architectural changes at the cellular and sub-cellular level. Since the cellular components that cause elastic scattering have dimensions typically on the order of visible to near-IR wavelengths, the elastic (Mie) scattering properties will be strongly wavelength dependent. Thus, morphology and size changes can be expected to cause significant changes in an optical signature that is derived from the wavelength-dependence of elastic scattering. The data acquisition and storage,display time with the OBS instrument is -1 second. Thus, in addition to the reduced invasiveness of this technique compared with current state-of-the-art methods (surgical biopsy and pathology analysis), the OBS offers the possibility of impressively faster diagnostic assessment. The OBS employs a small fiber-optic probe that is amenable to use with any endoscope, catheter or hypodermic, or to direct surface examination (e.g., as in skin cancer or cervical cancer). It has been tested in vitro on animal and human tissue samples, and clinical testing in vivo is currently in progress.

Original languageEnglish (US)
Pages (from-to)174-184
Number of pages11
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume2081
DOIs
StatePublished - Jan 15 1994
EventOptical Biopsy 1993 - Budapest, Hungary
Duration: Aug 29 1993Sep 3 1993

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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