Optical coherence tomography and intravascular ultrasound imaging of bioabsorbable magnesium stent degradation in porcine coronary arteries

Tina L.Pinto Slottow, Rajbabu Pakala, Teruo Okabe, David Hellinga, Rachel J. Lovec, Fermin O. Tio, Anh B. Bui, Ron Waksman

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Background: Absorbable metallic stents (AMS) composed of magnesium alloy were designed to complete degradation within 90-120 days. Among the potential advantages of these stents, when compared to conventional stents, are the elimination of late stent thrombosis, chronic inflammation, and artifacts during noninvasive imaging. Methods: Magnesium-based AMS were deployed in juvenile domestic pig coronary arteries. Angiography, optical coherence tomography (OCT), and intravascular ultrasound (IVUS) were performed before and after implant and then at 28 days and 3 months following stenting. The animals were sacrificed at 28 days or 3 months following stent implantation. Stented vessels were harvested and analyzed by histomorphometry. Results: Over time, OCT, IVUS, and histologic images revealed a progressive degradation of the stents. Mean stent strut width in the OCT images after implantation was 0.24±0.032 mm, then decreased to 0.12±0.007 mm (P<.0001) at 28 days and to 0.151±0.032 mm at 3 months (P<.0001 vs. implant, P=.078 vs. 28 days). Conclusion: Magnesium-based AMS degrade over a 3-month time period in a porcine model. Its structure is not apparent by angiography but is well-visualized by OCT and IVUS. OCT allowed quantitative assessment of stent degradation.

Original languageEnglish (US)
Pages (from-to)248-254
Number of pages7
JournalCardiovascular Revascularization Medicine
Volume9
Issue number4
DOIs
StatePublished - Oct 2008
Externally publishedYes

Keywords

  • Bioabsorbable stent
  • Intravascular ultrasound
  • Optical coherence tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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