Ontogeny of hematological cell and biochemical profiles in maternal and fetal baboons (Papio species)

Natalia E. Schlabritz-Loutsevitch, Gene B. Hubbard, Susan L. Jenkins, Helen C. Martin, Cathy S. Snider, Patrice A. Frost, M. Michelle Leland, Lorena M. Havill, Thomas J. McDonald, Peter W. Nathanielsz

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The normal ranges of hematological cell profiles and biochemistry are documented in adult non-pregnant, pregnant, juvenile, and neonatal baboons. Despite the extensive use of the baboon as a model for the study of various aspects of pregnancy, there is no data from paired mothers and their fetuses at different stages of gestation. Hematologic and biochemical profile data were obtained from eight non-pregnant female baboons, 37 mothers and 38 fetal baboons at 30 ± 2, 90 ± 2, 125 ± 2, and 175 ± 2 days of gestation (mean ± range; dGA; term, 180 dGA). Changes observed in fetal and maternal blood during normal baboon pregnancy were similar to those reported in human pregnancy. The level of alkaline phosphatase was two times higher in fetal blood circulation than that reported in human pregnancy.

Original languageEnglish (US)
Pages (from-to)193-200
Number of pages8
JournalJournal of medical primatology
Volume34
Issue number4
DOIs
StatePublished - Aug 2005

Keywords

  • Blood biochemistry
  • Blood hematology
  • Nonhuman primates
  • Pregnancy

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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