One-clip, one-kidney hypertension in rats with hereditary hypothalamic diabetes insipidus

Leonard Share, Joan T. Crofton, Won Jon Lee-Kwon, Robert E. Shade

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

An attempt was made to produce one-clip, one-kidney hypertension in the rat with diabetes insipidus (DI). Renal artery constriction in unilaterally nephrectomized DI rats (DI-clip) resulted in an increased blood pressure in all 9 rats, but this response was only transient in 3 rats. The magnitude of the hypertension was less in the DI-clip rats than in Long-Evans rats subjected to the same protocol (LE-clip). Infusion of saralasin i.v. at doses of 10 and 30 μg/kg·min. 4 to 6 weeks after surgery was without effect on mean arterial pressure in LE-clip and control DI rats, but substantially lowered blood pressure in the DI-clip rats (p < 0.05 - 0.01). It is concluded that vasopressin is not essential for the production of one-clip, one-kidney hypertension in the rat, and that, in the DI rat, the renin-angiotensin system is an important factor in this form of hypertension.

Original languageEnglish (US)
Pages (from-to)1261-1270
Number of pages10
JournalClinical and Experimental Hypertension
VolumeA4
Issue number8
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

Diabetes Insipidus
Surgical Instruments
Hypertension
Kidney
Saralasin
Blood Pressure
Long Evans Rats
Renal Artery
Renin-Angiotensin System
Vasopressins
Constriction
Arterial Pressure

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

Cite this

One-clip, one-kidney hypertension in rats with hereditary hypothalamic diabetes insipidus. / Share, Leonard; Crofton, Joan T.; Lee-Kwon, Won Jon; Shade, Robert E.

In: Clinical and Experimental Hypertension, Vol. A4, No. 8, 1982, p. 1261-1270.

Research output: Contribution to journalArticle

Share, Leonard ; Crofton, Joan T. ; Lee-Kwon, Won Jon ; Shade, Robert E. / One-clip, one-kidney hypertension in rats with hereditary hypothalamic diabetes insipidus. In: Clinical and Experimental Hypertension. 1982 ; Vol. A4, No. 8. pp. 1261-1270.
@article{ff0cfe1041d6490696d7f710d27c3a79,
title = "One-clip, one-kidney hypertension in rats with hereditary hypothalamic diabetes insipidus",
abstract = "An attempt was made to produce one-clip, one-kidney hypertension in the rat with diabetes insipidus (DI). Renal artery constriction in unilaterally nephrectomized DI rats (DI-clip) resulted in an increased blood pressure in all 9 rats, but this response was only transient in 3 rats. The magnitude of the hypertension was less in the DI-clip rats than in Long-Evans rats subjected to the same protocol (LE-clip). Infusion of saralasin i.v. at doses of 10 and 30 μg/kg·min. 4 to 6 weeks after surgery was without effect on mean arterial pressure in LE-clip and control DI rats, but substantially lowered blood pressure in the DI-clip rats (p < 0.05 - 0.01). It is concluded that vasopressin is not essential for the production of one-clip, one-kidney hypertension in the rat, and that, in the DI rat, the renin-angiotensin system is an important factor in this form of hypertension.",
author = "Leonard Share and Crofton, {Joan T.} and Lee-Kwon, {Won Jon} and Shade, {Robert E.}",
year = "1982",
doi = "10.3109/10641968209060788",
language = "English (US)",
volume = "A4",
pages = "1261--1270",
journal = "Clinical and Experimental Hypertension",
issn = "1064-1963",
publisher = "Informa Healthcare",
number = "8",

}

TY - JOUR

T1 - One-clip, one-kidney hypertension in rats with hereditary hypothalamic diabetes insipidus

AU - Share, Leonard

AU - Crofton, Joan T.

AU - Lee-Kwon, Won Jon

AU - Shade, Robert E.

PY - 1982

Y1 - 1982

N2 - An attempt was made to produce one-clip, one-kidney hypertension in the rat with diabetes insipidus (DI). Renal artery constriction in unilaterally nephrectomized DI rats (DI-clip) resulted in an increased blood pressure in all 9 rats, but this response was only transient in 3 rats. The magnitude of the hypertension was less in the DI-clip rats than in Long-Evans rats subjected to the same protocol (LE-clip). Infusion of saralasin i.v. at doses of 10 and 30 μg/kg·min. 4 to 6 weeks after surgery was without effect on mean arterial pressure in LE-clip and control DI rats, but substantially lowered blood pressure in the DI-clip rats (p < 0.05 - 0.01). It is concluded that vasopressin is not essential for the production of one-clip, one-kidney hypertension in the rat, and that, in the DI rat, the renin-angiotensin system is an important factor in this form of hypertension.

AB - An attempt was made to produce one-clip, one-kidney hypertension in the rat with diabetes insipidus (DI). Renal artery constriction in unilaterally nephrectomized DI rats (DI-clip) resulted in an increased blood pressure in all 9 rats, but this response was only transient in 3 rats. The magnitude of the hypertension was less in the DI-clip rats than in Long-Evans rats subjected to the same protocol (LE-clip). Infusion of saralasin i.v. at doses of 10 and 30 μg/kg·min. 4 to 6 weeks after surgery was without effect on mean arterial pressure in LE-clip and control DI rats, but substantially lowered blood pressure in the DI-clip rats (p < 0.05 - 0.01). It is concluded that vasopressin is not essential for the production of one-clip, one-kidney hypertension in the rat, and that, in the DI rat, the renin-angiotensin system is an important factor in this form of hypertension.

UR - http://www.scopus.com/inward/record.url?scp=0020320183&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020320183&partnerID=8YFLogxK

U2 - 10.3109/10641968209060788

DO - 10.3109/10641968209060788

M3 - Article

C2 - 7116667

AN - SCOPUS:0020320183

VL - A4

SP - 1261

EP - 1270

JO - Clinical and Experimental Hypertension

JF - Clinical and Experimental Hypertension

SN - 1064-1963

IS - 8

ER -