Oncogenic parallels in Alzheimer disease

Arun K. Raina, Matthew R. Garrett, Laura A. Previll, Mark E. Obrenovich, Anthony W. Hartzler, Kate M. Webber, Gemma Casadesus, Hyoung Gon Lee, George Perry, Xiongwei Zhu, Mark A. Smith

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Vulnerable neuronal populations in Alzheimer disease display a phenotype that is characteristic, in many ways, of cancer cells. This includes the ectopic expression of a hoard of proliferative cell cycle markers and aberrant activation of mitogenic and oncogenic signaling pathways. These findings have led us to hypothesize that neurodegeneration in Alzheimer disease, like cancer, is a disease of inappropriate cell cycle control. In this review, after a brief summary of cell cycle control, we discuss oncogenic and cell cycle alterations in Alzheimer disease and critically assess their relationship to other facets of disease pathogenesis.

Original languageEnglish (US)
Pages (from-to)80-85
Number of pages6
JournalInternational Journal of Neuroprotection and Neuroregeneration
Volume2
Issue number2
StatePublished - Feb 2006

Keywords

  • Alzheimer disease
  • Apoptosis
  • Cell cycle
  • Cyclin-dependent kinase
  • Oncogenesis
  • Oxidative stress
  • Presenilin-1

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology

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