Oncogenic parallels in Alzheimer disease

Arun K. Raina, Matthew R. Garrett, Laura A. Previll, Mark E. Obrenovich, Anthony Hartzler, Kate M. Webber, Gemma Casadesus, Hyoung Gon Lee, George Perry, Xiongwei Zhu, Mark A. Smith

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Vulnerable neuronal populations in Alzheimer disease display a phenotype that is characteristic, in many ways, of cancer cells. This includes the ectopic expression of a hoard of proliferative cell cycle markers and aberrant activation of mitogenic and oncogenic signaling pathways. These findings have led us to hypothesize that neurodegeneration in Alzheimer disease, like cancer, is a disease of inappropriate cell cycle control. In this review, after a brief summary of cell cycle control, we discuss oncogenic and cell cycle alterations in Alzheimer disease and critically assess their relationship to other facets of disease pathogenesis.

Original languageEnglish (US)
Pages (from-to)80-85
Number of pages6
JournalInternational Journal of Neuroprotection and Neuroregeneration
Volume2
Issue number2
StatePublished - Feb 2006
Externally publishedYes

Fingerprint

Alzheimer Disease
Cell Cycle Checkpoints
Cell Cycle
Vulnerable Populations
Neoplasms
Phenotype
Ectopic Gene Expression
Hoarding

Keywords

  • Alzheimer disease
  • Apoptosis
  • Cell cycle
  • Cyclin-dependent kinase
  • Oncogenesis
  • Oxidative stress
  • Presenilin-1

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology

Cite this

Raina, A. K., Garrett, M. R., Previll, L. A., Obrenovich, M. E., Hartzler, A., Webber, K. M., ... Smith, M. A. (2006). Oncogenic parallels in Alzheimer disease. International Journal of Neuroprotection and Neuroregeneration, 2(2), 80-85.

Oncogenic parallels in Alzheimer disease. / Raina, Arun K.; Garrett, Matthew R.; Previll, Laura A.; Obrenovich, Mark E.; Hartzler, Anthony; Webber, Kate M.; Casadesus, Gemma; Lee, Hyoung Gon; Perry, George; Zhu, Xiongwei; Smith, Mark A.

In: International Journal of Neuroprotection and Neuroregeneration, Vol. 2, No. 2, 02.2006, p. 80-85.

Research output: Contribution to journalArticle

Raina, AK, Garrett, MR, Previll, LA, Obrenovich, ME, Hartzler, A, Webber, KM, Casadesus, G, Lee, HG, Perry, G, Zhu, X & Smith, MA 2006, 'Oncogenic parallels in Alzheimer disease', International Journal of Neuroprotection and Neuroregeneration, vol. 2, no. 2, pp. 80-85.
Raina AK, Garrett MR, Previll LA, Obrenovich ME, Hartzler A, Webber KM et al. Oncogenic parallels in Alzheimer disease. International Journal of Neuroprotection and Neuroregeneration. 2006 Feb;2(2):80-85.
Raina, Arun K. ; Garrett, Matthew R. ; Previll, Laura A. ; Obrenovich, Mark E. ; Hartzler, Anthony ; Webber, Kate M. ; Casadesus, Gemma ; Lee, Hyoung Gon ; Perry, George ; Zhu, Xiongwei ; Smith, Mark A. / Oncogenic parallels in Alzheimer disease. In: International Journal of Neuroprotection and Neuroregeneration. 2006 ; Vol. 2, No. 2. pp. 80-85.
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