Abstract
Vulnerable neuronal populations in Alzheimer disease display a phenotype that is characteristic, in many ways, of cancer cells. This includes the ectopic expression of a hoard of proliferative cell cycle markers and aberrant activation of mitogenic and oncogenic signaling pathways. These findings have led us to hypothesize that neurodegeneration in Alzheimer disease, like cancer, is a disease of inappropriate cell cycle control. In this review, after a brief summary of cell cycle control, we discuss oncogenic and cell cycle alterations in Alzheimer disease and critically assess their relationship to other facets of disease pathogenesis.
Original language | English (US) |
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Pages (from-to) | 80-85 |
Number of pages | 6 |
Journal | International Journal of Neuroprotection and Neuroregeneration |
Volume | 2 |
Issue number | 2 |
State | Published - Feb 2006 |
Externally published | Yes |
Keywords
- Alzheimer disease
- Apoptosis
- Cell cycle
- Cyclin-dependent kinase
- Oncogenesis
- Oxidative stress
- Presenilin-1
ASJC Scopus subject areas
- Pharmacology
- Clinical Neurology