On the osmotically unresponsive water compartment in cells

Gary D. Fullerton, Kalpana M. Kanal, Ivan L. Cameron

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Differences in colligative properties (freezing point, boiling point, vapor pressure and osmotic behavior) between water in living cells and pure bulk water were investigated by re-evaluating reports of the osmotic behavior of mammalian cells. In five different animal cells, osmotically unresponsive water (OUW) values ranged from 1.1 to 2.2 g per g dry mass. Detailed analysis of human red blood cell (RBC) data indicates a major role for hemoglobin OUW-values, aggregation and packing in cell volume regulation that can be explained for the first time in relevant molecular terms.

Original languageEnglish (US)
Pages (from-to)74-77
Number of pages4
JournalCell Biology International
Volume30
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • Cell water
  • Interfacial water
  • Osmosis
  • Osmotically unresponsive water

ASJC Scopus subject areas

  • Cell Biology

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