On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune‐deprived mice

Janet A. Houghton, Peter J. Houghton

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Three fluorinated pyrimidines, 5‐fluorouracil (FUra), 5‐fluorouridine (FUrd), and 5‐fluoro‐2′‐dexoyuridine (FdUrd), have been studied in four human colonic tumor xenograft lines. The preliminary findings may be summarized as follows: 1) after equimolar dosages, the agent reaching the highest concentration in the tumor produced the highest level of fluorodeoxyuridylate (FdUMP); 2) within a tumor line, the order of response to the three agents is related to the order of FdUMP‐generation; 3) the tumor‐response did not correspond to the level of analogue‐incorporation into RNA; 4) the measurement of levels of free FdUMP in tumors is a poor prognostic indicator of drug‐response; and 5) the levels of FdUMP in the tumors are maintained for considerable periods and appear to be dependent upon the maintenance of the levels of either FUra or FUrd, irrespective of the parent agent administered.

Original languageEnglish (US)
Pages (from-to)1159-1167
Number of pages9
JournalCancer
Volume45
Issue number5 S
DOIs
StatePublished - Mar 15 1980
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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