Omega-3 fatty acid effect on alveolar bone loss in rats

L. Kesavalu, B. Vasudevan, B. Raghu, E. Browning, D. Dawson, J. M. Novak, M. C. Correll, M. J. Steffen, A. Bhattacharya, G. Fernandes, J. L. Ebersole

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Gingival inflammation and alveolar bone resorption are hallmarks of adult periodontitis, elicited in response to oral micro-organisms such as Porphyromonas gingivalis. We hypothesized that omega (ω)-3 fatty acids (FA) dietary supplementation would modulate inflammatory reactions leading to periodontal disease in infected rats. Rats were fed fish oil (ω-3 FA) or corn oil (n-6 FA) diets for 22 weeks and were infected with P. gingivalis. Rats on the ω-3 FA diet exhibited elevated serum levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), documenting diet-induced changes. PCR analyses demonstrated that rats were orally colonized by P. gingivalis; increased IgG antibody levels substantiated this infection. P. gingivalis-infected rats treated with ω-3 FA had significantly less alveolar bone resorption. These results demonstrated the effectiveness of an ω-3 FA-supplemented diet in modulating alveolar bone resorption following P. gingivalis infection, and supported that ω-3 FA may be a useful adjunct in the treatment of periodontal disease.

Original languageEnglish (US)
Pages (from-to)648-652
Number of pages5
JournalJournal of Dental Research
Volume85
Issue number7
DOIs
StatePublished - Jul 2006

Keywords

  • Alveolar bone loss
  • IgG antibody
  • P. gingivalis
  • Periodontal disease
  • ω-3 PUFA

ASJC Scopus subject areas

  • Dentistry(all)

Fingerprint Dive into the research topics of 'Omega-3 fatty acid effect on alveolar bone loss in rats'. Together they form a unique fingerprint.

  • Cite this

    Kesavalu, L., Vasudevan, B., Raghu, B., Browning, E., Dawson, D., Novak, J. M., Correll, M. C., Steffen, M. J., Bhattacharya, A., Fernandes, G., & Ebersole, J. L. (2006). Omega-3 fatty acid effect on alveolar bone loss in rats. Journal of Dental Research, 85(7), 648-652. https://doi.org/10.1177/154405910608500713