Olorofim demonstrates in vitro activity against Coccidioides species, including isolates against which fluconazole has reduced activity

Nathan P. Wiederhold; Hoja P. Patterson; Dora Ferrer; Victor Garcia; George R. Thompson; Thomas F. Patterson

doi:10.1128/aac.00988-24

Olorofim demonstrates in vitro activity against Coccidioides species, including isolates against which fluconazole has reduced activity

Nathan P. Wiederhold, Hoja P. Patterson, Dora Ferrer, Victor Garcia, George R. Thompson, Thomas F. Patterson

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated the in vitro activity of olorofim against Coccidioides species. Olorofim demonstrated potent in vitro activity against all isolates tested with a minimum inhibitory concentration (MIC) range ≤0.008–0.06 µg/mL and geometric mean MIC of 0.010 µg/mL. This activity was also maintained against isolates with elevated fluconazole MICs (≥16 µg/mL), including strains with MICs ≥32 µg/mL (olorofim MIC range ≤0.008–0.06 µg/mL and geometric mean MICs of ≤0.009 and ≤0.013 µg/mL, respectively).

Original language	English (US)
Journal	Antimicrobial agents and chemotherapy
Volume	69
Issue number	1
DOIs	https://doi.org/10.1128/aac.00988-24
State	Published - Jan 2025

Keywords

Coccidioides species
fluconazole
in vitro susceptibility
olorofim

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/aac.00988-24

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title = "Olorofim demonstrates in vitro activity against Coccidioides species, including isolates against which fluconazole has reduced activity",

abstract = "We evaluated the in vitro activity of olorofim against Coccidioides species. Olorofim demonstrated potent in vitro activity against all isolates tested with a minimum inhibitory concentration (MIC) range ≤0.008–0.06 µg/mL and geometric mean MIC of 0.010 µg/mL. This activity was also maintained against isolates with elevated fluconazole MICs (≥16 µg/mL), including strains with MICs ≥32 µg/mL (olorofim MIC range ≤0.008–0.06 µg/mL and geometric mean MICs of ≤0.009 and ≤0.013 µg/mL, respectively).",

keywords = "Coccidioides species, fluconazole, in vitro susceptibility, olorofim",

author = "Wiederhold, {Nathan P.} and Patterson, {Hoja P.} and Dora Ferrer and Victor Garcia and Thompson, {George R.} and Patterson, {Thomas F.}",

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doi = "10.1128/aac.00988-24",

language = "English (US)",

volume = "69",

journal = "Antimicrobial agents and chemotherapy",

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T1 - Olorofim demonstrates in vitro activity against Coccidioides species, including isolates against which fluconazole has reduced activity

AU - Wiederhold, Nathan P.

AU - Patterson, Hoja P.

AU - Ferrer, Dora

AU - Garcia, Victor

AU - Thompson, George R.

AU - Patterson, Thomas F.

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N2 - We evaluated the in vitro activity of olorofim against Coccidioides species. Olorofim demonstrated potent in vitro activity against all isolates tested with a minimum inhibitory concentration (MIC) range ≤0.008–0.06 µg/mL and geometric mean MIC of 0.010 µg/mL. This activity was also maintained against isolates with elevated fluconazole MICs (≥16 µg/mL), including strains with MICs ≥32 µg/mL (olorofim MIC range ≤0.008–0.06 µg/mL and geometric mean MICs of ≤0.009 and ≤0.013 µg/mL, respectively).

AB - We evaluated the in vitro activity of olorofim against Coccidioides species. Olorofim demonstrated potent in vitro activity against all isolates tested with a minimum inhibitory concentration (MIC) range ≤0.008–0.06 µg/mL and geometric mean MIC of 0.010 µg/mL. This activity was also maintained against isolates with elevated fluconazole MICs (≥16 µg/mL), including strains with MICs ≥32 µg/mL (olorofim MIC range ≤0.008–0.06 µg/mL and geometric mean MICs of ≤0.009 and ≤0.013 µg/mL, respectively).

KW - Coccidioides species

KW - fluconazole

KW - in vitro susceptibility

KW - olorofim

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VL - 69

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

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Olorofim demonstrates in vitro activity against Coccidioides species, including isolates against which fluconazole has reduced activity

Abstract

Keywords

ASJC Scopus subject areas

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