Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation

Emmanuelle Berret, Tara Barron, Jie Xu, Emily Debner, Eun Jung Kim, Jun H Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Oligodendrocyte (OL) maturation and axon-glial communication are required for proper myelination in the developing brain. However, physiological properties of OLs remain largely uncharacterized in different brain regions. The roles of oligodendroglial voltage-activated Na+ channels (Nav) and electrical excitability in relation to maturation to the myelinating stage are controversial, although oligodendroglial excitability is potentially important for promoting axon myelination. Here we show spiking properties of OLs and their role in axon-glial communication in the auditory brainstem. A subpopulation of pre-myelinating OLs (pre-OLs) can generate Nav1.2-driven action potentials throughout postnatal development to early adulthood. In addition, excitable pre-OLs receive glutamatergic inputs from neighboring neurons that trigger pre-OL spikes. Knockdown of Nav1.2 channels in pre-OLs alters their morphology, reduces axon-OL interactions and impairs myelination. Our results suggest that Nav1.2-driven spiking of pre-OLs is an integral component of axon-glial communication and is required for the function and maturation of OLs to promote myelination.

Original languageEnglish (US)
Article number557
JournalNature Communications
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2017

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axons
Axons
Chemical activation
activation
Neuroglia
spiking
communication
Oligodendroglia
brain
Brain
Communication
neurons
spikes
Action Potentials
Brain Stem
Neurons
actuators
Electric potential
electric potential
interactions

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation. / Berret, Emmanuelle; Barron, Tara; Xu, Jie; Debner, Emily; Kim, Eun Jung; Kim, Jun H.

In: Nature Communications, Vol. 8, No. 1, 557, 01.12.2017.

Research output: Contribution to journalArticle

Berret, Emmanuelle ; Barron, Tara ; Xu, Jie ; Debner, Emily ; Kim, Eun Jung ; Kim, Jun H. / Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation. In: Nature Communications. 2017 ; Vol. 8, No. 1.
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