Olfactomedin-like 3 (OLFML3) gene expression in baboon and human ocular tissues: Cornea, lens, uvea, and retina

I. P. Rodríguez-Sánchez; M. L. Garza-Rodríguez; K. Mohamed-Noriega; V. S. Voruganti; M. E. Tejero; I. Delgado-Enciso; D. C. Pérez-Ibave; N. E. Schlabritz-Loutsevitch; J. Mohamed-Noriega; M. L. Martinez-Fierro; D. Reséndez-Pérez; S. A. Cole; H. Cavazos-Adame; A. G. Comuzzie; J. Mohamed-Hamsho; H. A. Barrera-Saldaña

doi:10.1111/jmp.12037

Olfactomedin-like 3 (OLFML3) gene expression in baboon and human ocular tissues: Cornea, lens, uvea, and retina

I. P. Rodríguez-Sánchez, M. L. Garza-Rodríguez, K. Mohamed-Noriega, V. S. Voruganti, M. E. Tejero, I. Delgado-Enciso, D. C. Pérez-Ibave, N. E. Schlabritz-Loutsevitch, J. Mohamed-Noriega, M. L. Martinez-Fierro, D. Reséndez-Pérez, S. A. Cole, H. Cavazos-Adame, A. G. Comuzzie, J. Mohamed-Hamsho, H. A. Barrera-Saldaña

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: Olfactomedin-like is a family of polyfunctional polymeric glycoproteins. This family has at least four members. One member of this family is OLFML3, which is preferentially expressed in placenta but is also detected in other adult tissues including the liver and heart. However, its orthologous rat gene is expressed in the iris, sclera, trabecular meshwork, retina, and optic nerve. Methods: OLFML3 messenger amplification was performed by RT-PCR from human and baboon ocular tissues. The products were cloned and sequenced. Results: We report OLFML3 expression in human and baboon eye. The full coding DNA sequence has 1221 bp, from which an open reading frame of 406 amino acid was obtained. The baboon OLFML3 gene nucleotidic sequence has 98% and amino acidic 99% similarity with humans. Conclusions: OLFML3 gene expression in human and baboon ocular tissues and its high similarity make the baboon a powerful model to deduce the physiological and/or metabolic function of this protein in the eye.

Original language	English (US)
Pages (from-to)	105-111
Number of pages	7
Journal	Journal of medical primatology
Volume	42
Issue number	3
DOIs	https://doi.org/10.1111/jmp.12037
State	Published - Jun 2013
Externally published	Yes

Keywords

Animal model
Corneal vascularization
Eye
Gene expression
Old World Monkey
Olfactomedin

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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Rodríguez-Sánchez, I. P., Garza-Rodríguez, M. L., Mohamed-Noriega, K., Voruganti, V. S., Tejero, M. E., Delgado-Enciso, I., Pérez-Ibave, D. C., Schlabritz-Loutsevitch, N. E., Mohamed-Noriega, J., Martinez-Fierro, M. L., Reséndez-Pérez, D., Cole, S. A., Cavazos-Adame, H., Comuzzie, A. G., Mohamed-Hamsho, J., & Barrera-Saldaña, H. A. (2013). Olfactomedin-like 3 (OLFML3) gene expression in baboon and human ocular tissues: Cornea, lens, uvea, and retina. Journal of medical primatology, 42(3), 105-111. https://doi.org/10.1111/jmp.12037

Rodríguez-Sánchez, IP, Garza-Rodríguez, ML, Mohamed-Noriega, K, Voruganti, VS, Tejero, ME, Delgado-Enciso, I, Pérez-Ibave, DC, Schlabritz-Loutsevitch, NE, Mohamed-Noriega, J, Martinez-Fierro, ML, Reséndez-Pérez, D, Cole, SA, Cavazos-Adame, H, Comuzzie, AG, Mohamed-Hamsho, J & Barrera-Saldaña, HA 2013, 'Olfactomedin-like 3 (OLFML3) gene expression in baboon and human ocular tissues: Cornea, lens, uvea, and retina', Journal of medical primatology, vol. 42, no. 3, pp. 105-111. https://doi.org/10.1111/jmp.12037

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title = "Olfactomedin-like 3 (OLFML3) gene expression in baboon and human ocular tissues: Cornea, lens, uvea, and retina",

abstract = "Background: Olfactomedin-like is a family of polyfunctional polymeric glycoproteins. This family has at least four members. One member of this family is OLFML3, which is preferentially expressed in placenta but is also detected in other adult tissues including the liver and heart. However, its orthologous rat gene is expressed in the iris, sclera, trabecular meshwork, retina, and optic nerve. Methods: OLFML3 messenger amplification was performed by RT-PCR from human and baboon ocular tissues. The products were cloned and sequenced. Results: We report OLFML3 expression in human and baboon eye. The full coding DNA sequence has 1221 bp, from which an open reading frame of 406 amino acid was obtained. The baboon OLFML3 gene nucleotidic sequence has 98% and amino acidic 99% similarity with humans. Conclusions: OLFML3 gene expression in human and baboon ocular tissues and its high similarity make the baboon a powerful model to deduce the physiological and/or metabolic function of this protein in the eye.",

keywords = "Animal model, Corneal vascularization, Eye, Gene expression, Old World Monkey, Olfactomedin",

author = "Rodr{\'i}guez-S{\'a}nchez, {I. P.} and Garza-Rodr{\'i}guez, {M. L.} and K. Mohamed-Noriega and Voruganti, {V. S.} and Tejero, {M. E.} and I. Delgado-Enciso and P{\'e}rez-Ibave, {D. C.} and Schlabritz-Loutsevitch, {N. E.} and J. Mohamed-Noriega and Martinez-Fierro, {M. L.} and D. Res{\'e}ndez-P{\'e}rez and Cole, {S. A.} and H. Cavazos-Adame and Comuzzie, {A. G.} and J. Mohamed-Hamsho and Barrera-Salda{\~n}a, {H. A.}",

year = "2013",

month = jun,

doi = "10.1111/jmp.12037",

language = "English (US)",

volume = "42",

pages = "105--111",

journal = "Journal of Medical Primatology",

issn = "0047-2565",

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number = "3",

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TY - JOUR

T1 - Olfactomedin-like 3 (OLFML3) gene expression in baboon and human ocular tissues

T2 - Cornea, lens, uvea, and retina

AU - Rodríguez-Sánchez, I. P.

AU - Garza-Rodríguez, M. L.

AU - Mohamed-Noriega, K.

AU - Voruganti, V. S.

AU - Tejero, M. E.

AU - Delgado-Enciso, I.

AU - Pérez-Ibave, D. C.

AU - Schlabritz-Loutsevitch, N. E.

AU - Mohamed-Noriega, J.

AU - Martinez-Fierro, M. L.

AU - Reséndez-Pérez, D.

AU - Cole, S. A.

AU - Cavazos-Adame, H.

AU - Comuzzie, A. G.

AU - Mohamed-Hamsho, J.

AU - Barrera-Saldaña, H. A.

PY - 2013/6

Y1 - 2013/6

N2 - Background: Olfactomedin-like is a family of polyfunctional polymeric glycoproteins. This family has at least four members. One member of this family is OLFML3, which is preferentially expressed in placenta but is also detected in other adult tissues including the liver and heart. However, its orthologous rat gene is expressed in the iris, sclera, trabecular meshwork, retina, and optic nerve. Methods: OLFML3 messenger amplification was performed by RT-PCR from human and baboon ocular tissues. The products were cloned and sequenced. Results: We report OLFML3 expression in human and baboon eye. The full coding DNA sequence has 1221 bp, from which an open reading frame of 406 amino acid was obtained. The baboon OLFML3 gene nucleotidic sequence has 98% and amino acidic 99% similarity with humans. Conclusions: OLFML3 gene expression in human and baboon ocular tissues and its high similarity make the baboon a powerful model to deduce the physiological and/or metabolic function of this protein in the eye.

AB - Background: Olfactomedin-like is a family of polyfunctional polymeric glycoproteins. This family has at least four members. One member of this family is OLFML3, which is preferentially expressed in placenta but is also detected in other adult tissues including the liver and heart. However, its orthologous rat gene is expressed in the iris, sclera, trabecular meshwork, retina, and optic nerve. Methods: OLFML3 messenger amplification was performed by RT-PCR from human and baboon ocular tissues. The products were cloned and sequenced. Results: We report OLFML3 expression in human and baboon eye. The full coding DNA sequence has 1221 bp, from which an open reading frame of 406 amino acid was obtained. The baboon OLFML3 gene nucleotidic sequence has 98% and amino acidic 99% similarity with humans. Conclusions: OLFML3 gene expression in human and baboon ocular tissues and its high similarity make the baboon a powerful model to deduce the physiological and/or metabolic function of this protein in the eye.

KW - Animal model

KW - Corneal vascularization

KW - Eye

KW - Gene expression

KW - Old World Monkey

KW - Olfactomedin

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Olfactomedin-like 3 (OLFML3) gene expression in baboon and human ocular tissues: Cornea, lens, uvea, and retina

Abstract

Keywords

ASJC Scopus subject areas

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