Older Stroke Patients with High Stroke Scores Have Delayed Door-To-Needle Times

Lee A. Birnbaum, Jesse S. Rodriguez, Christopher H. Topel, Reza Behrouz, Vivek Misra, Santiago Palacio, Michele G. Patterson, Deb S. Motz, Martin W. Goros, John E. Cornell, Jean Louis R. Caron

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Introduction The timely administration of intravenous (IV) tissue plasminogen activator (t-PA) to acute ischemic stroke patients from the period of symptom presentation to treatment, door-to-needle (DTN) time, is an important focus for quality improvement and best clinical practice. Methods A retrospective review of our Get With The Guidelines database was performed for a 5-hospital telestroke network for the period between January 2010 and January 2015. All acute ischemic stroke patients who were triaged in the emergency departments connected to the telestroke network and received IV t-PA were included. Optimal DTN time was defined as less than 60 minutes. Logistic regression was performed with clinical variables associated with DTN time. Age and National Institutes of Health Stroke Scale (NIHSS) score were categorized based on clinically significant cutoffs. Results Six-hundred and fifty-two patients (51% women, 46% White, 45% Hispanic, and 8% Black) were included in this study. The mean age was 70 years (range 29-98). Of the variables analyzed, only arrival mode, initial NIHSS score, and the interaction between age and initial NIHSS score were significant. DTN time more than or equal to 60 minutes was most common in patients aged more than 80 years with NIHSS score higher than 10. Conclusions The cause of DTN time delay for older patients with higher NIHSS score is unclear but was not related to presenting blood pressure or arrival mode. Further study of this subgroup is important to reduce overall DTN times.

Original languageEnglish (US)
Pages (from-to)2668-2672
Number of pages5
JournalJournal of Stroke and Cerebrovascular Diseases
Issue number11
StatePublished - Nov 1 2016


  • Acute ischemic stroke
  • antithrombotic
  • stroke treatment
  • tissue plasminogen activator

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Rehabilitation
  • Surgery


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