Olanzapine transfer by human placenta

S. Schenker, Y. Yang, E. Mattiuz, D. Tatum, M. Lee

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

1. The present study assessed the human transplacental transport of olanzapine, a new antipsychotic drug effective in the treatment of schizophrenia. 2. Using the normal-term placenta perfused single cotyledon system, we show that: (i) 5-14% of labelled olanzapine crosses from the maternal to foetal compartments in 4 h; (ii) transport depends significantly on binding characteristics, especially of albumin; (iii) no oxidative metabolites of olanzapine appear in the placental perfusate over 4 h; and (iv) approximately 17% of olanzapine, on average, is converted to the glucuronide, which is transferred by the placenta at a rate slightly slower than the parent drug.

Original languageEnglish (US)
Pages (from-to)691-697
Number of pages7
JournalClinical and Experimental Pharmacology and Physiology
Volume26
Issue number9
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Olanzapine
  • Placenta
  • Transplacental transport

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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