Occurrence of circulating immune complexes in β-thalassaemia major

The presence of circulating soluble immune complexes and the level of complement were investigated in sera from 21 patients with β thalassaemia major, including both splenectomised and nonsplenectomised patients. A high level of immune complexes was found in half of these cases. Reduced complement levels were seen less frequently. There was no correlation between the presence of circulating immune complexes, decreased complement levels, and the presence or absence of the spleen. The level of immune complexes increased with the age of the individual, i.e. with the duration of the disease.