Occlusion of the neonatal patent ductus arteriosus with a simple retrievable device: A feasibility study

Malte B. Neuß, James Y. Coe, Fermin Tio, Trong Phi Le, Ralph Grabitz, Dirk A. Redel

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Purpose: To examine the feasibility of transvenous placement of a new memory-shaped, small, retrievable coil that has a smaller-caliber delivery system than currently available devices, for closure of the patent ductus arteriosus (PDA). Methods: Through 4 or 5 Fr vascular sheaths and 4 or 5 Fr end-hold catheters, the coils were delivered and placed in piglets (n = 10) with PDA. The coils were made from 0.018'' (0.46 mm) or 0.028'' (0.71 mm) stainless steel guidewire. Mounted for delivery, the new device has the appearance of a conventional guidewire. This neonatal PDA model was created without major surgery or drugs by stenting the ductus arteriosus. Results: The memory-shaped coils were easily delivered. Coils not optimally placed were retrieved and repositioned. Occlusion of the ductus arteriosus as early as a half-hour after delivery was shown angiographically and confirmed by histopathology. Conclusion: This new, small-caliber, simple device was found to be effective for closure of the PDA in this animal model. Longer-term observations are needed.

Original languageEnglish (US)
Pages (from-to)170-175
Number of pages6
JournalCardiovascular and Interventional Radiology
Volume19
Issue number3
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Catheter occlusion
  • Memory-shaped coils
  • Newborn piglets
  • PDA
  • Stents

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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